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SHP2在非小细胞肺癌中的表达及意义

BACKGROUND AND OBJECTIVE: Precious studies proven that aberrant tyrosine phosphorylation has linked with cancer.The aim of this work is to study the expression and significance of SHP2 in non-small cell lung cancer (NSCLC) through tissue microarray technique and immunohistochemical method. METHODS:...

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Detalles Bibliográficos
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 中国肺癌杂志编辑部 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6000528/
https://www.ncbi.nlm.nih.gov/pubmed/20673499
http://dx.doi.org/10.3779/j.issn.1009-3419.2010.02.03
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collection PubMed
description BACKGROUND AND OBJECTIVE: Precious studies proven that aberrant tyrosine phosphorylation has linked with cancer.The aim of this work is to study the expression and significance of SHP2 in non-small cell lung cancer (NSCLC) through tissue microarray technique and immunohistochemical method. METHODS: Eighty NSCLC specimens were constructed into tissue microarray and performed using immunohistochemistry. RESULTS: The total positive rates of SHP2 were 70.7% (56/80) in NSCLC, 72.5% (29/40) in squamous cell carcinoma and 75% (27/40) in adenocarcinoma, which was not significant difference in sex, age, the size of tumor, histology, clinical stages and differentiation (P > 0.05), the positive rates of SHP2 were significantly higher in the cases with lymphnode metastasis than those without (P < 0.05). CONCLUSION: The expression rate of SHP2 is high and closely correlated to lymphnode metastasis in NSCLC, which implies the occurrence and development of lung cancer may be related to SHP2, and SHP2 may be a new marker and therapeutic targets for lung cancer.
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spelling pubmed-60005282018-07-06 SHP2在非小细胞肺癌中的表达及意义 Zhongguo Fei Ai Za Zhi 临床研究 BACKGROUND AND OBJECTIVE: Precious studies proven that aberrant tyrosine phosphorylation has linked with cancer.The aim of this work is to study the expression and significance of SHP2 in non-small cell lung cancer (NSCLC) through tissue microarray technique and immunohistochemical method. METHODS: Eighty NSCLC specimens were constructed into tissue microarray and performed using immunohistochemistry. RESULTS: The total positive rates of SHP2 were 70.7% (56/80) in NSCLC, 72.5% (29/40) in squamous cell carcinoma and 75% (27/40) in adenocarcinoma, which was not significant difference in sex, age, the size of tumor, histology, clinical stages and differentiation (P > 0.05), the positive rates of SHP2 were significantly higher in the cases with lymphnode metastasis than those without (P < 0.05). CONCLUSION: The expression rate of SHP2 is high and closely correlated to lymphnode metastasis in NSCLC, which implies the occurrence and development of lung cancer may be related to SHP2, and SHP2 may be a new marker and therapeutic targets for lung cancer. 中国肺癌杂志编辑部 2010-02-20 /pmc/articles/PMC6000528/ /pubmed/20673499 http://dx.doi.org/10.3779/j.issn.1009-3419.2010.02.03 Text en 版权所有©《中国肺癌杂志》编辑部2010 https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed in accordance with the terms of the Creative Commons Attribution (CC BY 3.0) License. See: https://creativecommons.org/licenses/by/3.0/
spellingShingle 临床研究
SHP2在非小细胞肺癌中的表达及意义
title SHP2在非小细胞肺癌中的表达及意义
title_full SHP2在非小细胞肺癌中的表达及意义
title_fullStr SHP2在非小细胞肺癌中的表达及意义
title_full_unstemmed SHP2在非小细胞肺癌中的表达及意义
title_short SHP2在非小细胞肺癌中的表达及意义
title_sort shp2在非小细胞肺癌中的表达及意义
topic 临床研究
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6000528/
https://www.ncbi.nlm.nih.gov/pubmed/20673499
http://dx.doi.org/10.3779/j.issn.1009-3419.2010.02.03
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