多发肺转移结节(125)I粒子植入技巧及临床应用

BACKGROUND AND OBJECTIVE: (125)I seed implantation treatment of pulmonary metastases, often because of complicated structure of the chest, was considered as restricted areas. The aim of this study is to evaluate the effectiveness of CT guided radioactive (125)I seed implantation in treating lung metastatic tumors. METHODS: Totally 115 metastatic masses were found in 30 patients with CT guiding. (125)I seeds were implanted into lung metastatic masses. The approach of implantation was determined according to the location of the lesions (hilar masses, peripheral masses and masses covered by skeletal thorax). The therapeutic effects were evaluated by CT. RESULTS: Uniform distribution were achieved by single puncture in 84.3% of patients. The rest patients (15.7%) were received replanting. The follow-up period was 6-24 months (mean 14.6). Among 115 lesions in 30 cases, complete response (CR) was achieved in 80 nodes, partial response (PR) in 20 nodes, No change (NC) in 8 nodes and progressive disease (PD) in 7 nodes. The total response rate was 86.9%. The one-year local control rate were 93.9% (108/115). No severe perioperative complications occurred. CONCLUSION: CT guided radioactive seed (125)I implantation is a safe and effective procedure in treating multiple lung metastatic tumor with minimal invasion.