非小细胞肺癌DNA甲基化研究进展

Genomic DNA methylation is a major form of epigenetic modification. Hypermethylation could affect the binding of transcription factors to DNA and change the structure of chromatin resulting in silence of tumor suppressor genes, which plays an important role in cancer initiation and progression. In r...

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Detalles Bibliográficos
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 中国肺癌杂志编辑部 2010
Materias:
综述
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6000552/
https://www.ncbi.nlm.nih.gov/pubmed/20704826
http://dx.doi.org/10.3779/j.issn.1009-3419.2010.08.14
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collection PubMed
description Genomic DNA methylation is a major form of epigenetic modification. Hypermethylation could affect the binding of transcription factors to DNA and change the structure of chromatin resulting in silence of tumor suppressor genes, which plays an important role in cancer initiation and progression. In recent years, the study of DNA methylation in lung cancer, mostly in non-small cell lung cancer, has made great progress and become a new target for early detection, risk assessment, prognosis and cancer therapy.
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spelling pubmed-60005522018-07-06 非小细胞肺癌DNA甲基化研究进展 Zhongguo Fei Ai Za Zhi 综述 Genomic DNA methylation is a major form of epigenetic modification. Hypermethylation could affect the binding of transcription factors to DNA and change the structure of chromatin resulting in silence of tumor suppressor genes, which plays an important role in cancer initiation and progression. In recent years, the study of DNA methylation in lung cancer, mostly in non-small cell lung cancer, has made great progress and become a new target for early detection, risk assessment, prognosis and cancer therapy. 中国肺癌杂志编辑部 2010-08-20 /pmc/articles/PMC6000552/ /pubmed/20704826 http://dx.doi.org/10.3779/j.issn.1009-3419.2010.08.14 Text en 版权所有©《中国肺癌杂志》编辑部2010 https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed in accordance with the terms of the Creative Commons Attribution (CC BY 3.0) License. See: https://creativecommons.org/licenses/by/3.0/
spellingShingle 综述
非小细胞肺癌DNA甲基化研究进展
title 非小细胞肺癌DNA甲基化研究进展
title_full 非小细胞肺癌DNA甲基化研究进展
title_fullStr 非小细胞肺癌DNA甲基化研究进展
title_full_unstemmed 非小细胞肺癌DNA甲基化研究进展
title_short 非小细胞肺癌DNA甲基化研究进展
title_sort 非小细胞肺癌dna甲基化研究进展
topic 综述
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6000552/
https://www.ncbi.nlm.nih.gov/pubmed/20704826
http://dx.doi.org/10.3779/j.issn.1009-3419.2010.08.14

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