CypA的生物学功能及其与肺癌相关的研究进展

CypA is the most important member of Cyclophilins. It is a widely expressed protein in nature possess-ing PPIase and chaperone activities which help the precise folding of protein. Also, it is involved in immunosuppression, inflam-mation and the balance of cholesterol. As the understanding of CypA function has deepened, people began to realize that there might exist a relationship between CypA and cancer. Lung cancer is the first carcinoma which was found as expressing high level of CypA. CypA plays the roles in increasing proliferation, antiapoptosis, invasion and metastasis in lung cancer. The study of CypA may open a new window for the early diagnosis, prognosis and novel therapeutic drugs targeting.