肺腺癌组织中OCT4表达与患者临床指标及预后的相关性

BACKGROUND AND OBJECTIVE: In recent years, cases of lung adenocarcinoma morbidity have consistently grown.OCT4 is the key gene that controls the automatic renewal of stem cells, and regulates the proliferation and differentiation of cancer stem cells.The aim of this study is to detect OCT4 expression in lung adenocarcinoma tissues, and to evaluate its relevance in the metastasis, chemotherapeutic effect, and prognosis in lung adenocarcinoma patients. METHODS: Immunofluorescence method was employed to detect OCT4 expression in lung adenocarcinoma tissues.The relationship between OCT4 expression and clinical pathological indicators is examined through chi-square test.Moreover, the survival rate is calculated through the Kaplan-Meier survivorship curve.Finally, the relevance between the indicators and patient survival is estimated using Cox analysis. RESULTS: Among the 126 tissue samples of lung adenocarcinoma, 91 showed OCT4 positive cells.OCT4 expression is closely related to metastasis and chemoresistance in lung adenocarcinoma patients, and negatively corresponds to the patients' disease-free survival and survival periods. CONCLUSION: OCT4 expression is related to metastasis and chemoresistance in lung adenocarcinoma patients, and thus indicates poor prognosis.