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手术在非小细胞肺癌单发脑转移治疗中的作用分析
BACKGROUND AND OBJECTIVE: Brain metastases are common in non-small cell lung cancer. Usual treatments include radiotherapy and chemotherapy. However, these methods result in poor patient prognosis. The aim of this study is to assess the effectiveness of surgical resection in the multimodality manage...
Formato: | Online Artículo Texto |
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Lenguaje: | English |
Publicado: |
中国肺癌杂志编辑部
2013
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6000643/ https://www.ncbi.nlm.nih.gov/pubmed/24345489 http://dx.doi.org/10.3779/j.issn.1009-3419.2013.12.05 |
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collection | PubMed |
description | BACKGROUND AND OBJECTIVE: Brain metastases are common in non-small cell lung cancer. Usual treatments include radiotherapy and chemotherapy. However, these methods result in poor patient prognosis. The aim of this study is to assess the effectiveness of surgical resection in the multimodality management of non-small cell lung cancer patients with synchronous solitary brain metastasis. METHODS: The clinical data of 46 non-small cell lung cancer patients with synchronous solitary brain metastasis were retrospectively reviewed. All patients underwent surgical resection of primary lung tumor, followed by whole brain radiotherapy and chemotherapy. In addition, 13 out of the 46 patients underwent resection of brain metastasis, whereas the remaining 33 patients received stereotactic radiosurgery. RESULTS: The median survival time of the enrolled patients was 16.8 months. The 1-, 2-, and 3-year survival rates were 76.1%, 20.9%, and 4.7%, respectively. The median survival times of the patients with brain metastasis resection or stereotactic radiosurgery were 18.3 and 15.8 months, respectively (P=0.091, 2). CONCLUSION: Surgical resection of primary lung tumor and brain metastasis may improve prognosis of non-small cell lung cancer patients with synchronous solitary brain metastasis. However, the survival benefit of surgical resection over brain metastasis resection or stereotactic radiosurgery is uncertain. |
format | Online Article Text |
id | pubmed-6000643 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | 中国肺癌杂志编辑部 |
record_format | MEDLINE/PubMed |
spelling | pubmed-60006432018-07-06 手术在非小细胞肺癌单发脑转移治疗中的作用分析 Zhongguo Fei Ai Za Zhi 临床研究 BACKGROUND AND OBJECTIVE: Brain metastases are common in non-small cell lung cancer. Usual treatments include radiotherapy and chemotherapy. However, these methods result in poor patient prognosis. The aim of this study is to assess the effectiveness of surgical resection in the multimodality management of non-small cell lung cancer patients with synchronous solitary brain metastasis. METHODS: The clinical data of 46 non-small cell lung cancer patients with synchronous solitary brain metastasis were retrospectively reviewed. All patients underwent surgical resection of primary lung tumor, followed by whole brain radiotherapy and chemotherapy. In addition, 13 out of the 46 patients underwent resection of brain metastasis, whereas the remaining 33 patients received stereotactic radiosurgery. RESULTS: The median survival time of the enrolled patients was 16.8 months. The 1-, 2-, and 3-year survival rates were 76.1%, 20.9%, and 4.7%, respectively. The median survival times of the patients with brain metastasis resection or stereotactic radiosurgery were 18.3 and 15.8 months, respectively (P=0.091, 2). CONCLUSION: Surgical resection of primary lung tumor and brain metastasis may improve prognosis of non-small cell lung cancer patients with synchronous solitary brain metastasis. However, the survival benefit of surgical resection over brain metastasis resection or stereotactic radiosurgery is uncertain. 中国肺癌杂志编辑部 2013-12-20 /pmc/articles/PMC6000643/ /pubmed/24345489 http://dx.doi.org/10.3779/j.issn.1009-3419.2013.12.05 Text en 版权所有©《中国肺癌杂志》编辑部2013 https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed in accordance with the terms of the Creative Commons Attribution (CC BY 3.0) License. See: https://creativecommons.org/licenses/by/3.0/ |
spellingShingle | 临床研究 手术在非小细胞肺癌单发脑转移治疗中的作用分析 |
title | 手术在非小细胞肺癌单发脑转移治疗中的作用分析 |
title_full | 手术在非小细胞肺癌单发脑转移治疗中的作用分析 |
title_fullStr | 手术在非小细胞肺癌单发脑转移治疗中的作用分析 |
title_full_unstemmed | 手术在非小细胞肺癌单发脑转移治疗中的作用分析 |
title_short | 手术在非小细胞肺癌单发脑转移治疗中的作用分析 |
title_sort | 手术在非小细胞肺癌单发脑转移治疗中的作用分析 |
topic | 临床研究 |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6000643/ https://www.ncbi.nlm.nih.gov/pubmed/24345489 http://dx.doi.org/10.3779/j.issn.1009-3419.2013.12.05 |
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