晚期肺癌患者肺功能指标与患者生存期的相关性研究

BACKGROUND AND OBJECTIVE: To those patients with advanced lung cancer, the ultimate objective is to improve the curative effect and quality of life, lung function indexes are an important factor. We investigate the change of lung function and the relationship between pulmonary function indexs and survival time in patients with advanced lung cancer. METHODS: Lung function was detected in 59 cases with lung cancer and 63 normal controls. The relationship between pulmonary function indexs and survival time was analyzed. RESULTS: There was significant difference in ventilation function and diffusing capacity between in lung cancer group and control group. Vital capacity (VC), forced expiratory volume in one second (FEV(1)), forced vital capacity (FVC), peak expiratory flow (PEF), peak expiratory flow% (PEF%), maximal ventilatory volume (MVV) were positively correlated with survival time in patients with advanced lung cancer (r=0.29, 0.28, 0.28, 0.27, 0.26, 0.28, P < 0.05), residual volume/total lung capacity was negatively correlated with survival time (r=-0.31, P < 0.05). CONCLUSION: The lung function decreases in the patients with lung cancer. VC, FEV(1), FVC, PEF, PEF%, MVV, residual volume/total lung capacity were correlated with survival time in patients with advanced lung cancer. The pulmonary function indexs were important marker of prognosis in patients with lung cancer.