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二甲双胍通过激活腺苷酸活化蛋白激酶(AMPK)的抗肿瘤机制

Metformin, as a traditional oral hypoglycemic agent, is commonly used in the clinical treatment for type 2 diabetes. Recently, a large number of epidemiological researches have shown that metformin could reduce the tumor morbidity of type 2 diabetes, moreover, it has also been indicated that metform...

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Detalles Bibliográficos
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 中国肺癌杂志编辑部 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6000667/
https://www.ncbi.nlm.nih.gov/pubmed/23945247
http://dx.doi.org/10.3779/j.issn.1009-3419.2013.08.07
Descripción
Sumario:Metformin, as a traditional oral hypoglycemic agent, is commonly used in the clinical treatment for type 2 diabetes. Recently, a large number of epidemiological researches have shown that metformin could reduce the tumor morbidity of type 2 diabetes, moreover, it has also been indicated that metformin could inhibit the growth, proliferation and transformation of cancer cells in metabolic pathways, cell cycle, oxidative stress and cancer/tumor stem cells transformation via AMPK pathway activation. But the antitumor e?ect of metformin via AMPK activation still exists arguments, and the defnite mechanism remains to be further investigated and confrmed by extensive clinical trials.