DNA修复基因XPD G312A多态性与肺癌易感性关系的meta分析

BACKGROUND AND OBJECTIVE: It has been proven that close relation was existed between XPD polymorphism G312A and lung cancer risk. However, some of the results are not consistent. The aim of this study is to explore the impact of DNA repair gene XPD polymorphism G312A on lung cancer risk. METHODS: The literatures eligible from PUBMED, EMBASE, CNKI and WANGFANG database were enrolled in the meta-analysis. Heterogeneity among combined studies was assessed. The pooled OR and 95%CI were calculated. The sensitivity analysis and the publication bias were evaluated by Rev-Man 5.0 and STATA 11.0. RESULTS: There were 6 554 cases and 8 322 controls from 18 studies included in the meta-analysis. In total, individuals with 312A allele and 312AA genotype showed increased lung cancer risk (A vs G: OR=1.06, 95%CI: 1.00-1.12; AA vs AG+GG: OR=1.20, 95%CI: 1.06-1.36; AA vs GG: OR=1.19, 95%CI: 1.04-1.36). In Asians, individuals with 312AA genotype showed 6.15 fold and 6.20 fold increased lung cancer risk in recessive genetic model and homogenous contrast respectively (AA vs AG+GG: OR=7.15, 95%CI: 1.90-26.94; AA vs GG: OR=7.20, 95%CI: 1.91-27.15). In Caucasians, individuals with 312AA genotype showed a 15% increased lung cancer risk (OR=1.15, 95%CI: 1.01-1.31). CONCLUSION: XPD 312A allele is risk allele for lung cancer. Individuals with AA genotype have higher risk of lung cancer, especially in Asians.