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ERCC1表达对Ⅰ期非小细胞肺癌患者术后生存率的影响

BACKGROUND AND OBJECTIVE: Proteins of the nucleotide excision repair pathway can repair DNA damage. The excision repair cross-complementing (ERCC) gene family reduce damagement of DNA by nucleotide excision and repair. The aim of this study is to investigate the expressions of ERCC1 (members of DNA...

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Detalles Bibliográficos
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 中国肺癌杂志编辑部 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6000703/
https://www.ncbi.nlm.nih.gov/pubmed/20677653
http://dx.doi.org/10.3779/j.issn.1009-3419.2010.05.26
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collection PubMed
description BACKGROUND AND OBJECTIVE: Proteins of the nucleotide excision repair pathway can repair DNA damage. The excision repair cross-complementing (ERCC) gene family reduce damagement of DNA by nucleotide excision and repair. The aim of this study is to investigate the expressions of ERCC1 (members of DNA repair gene family) in patients with non-small cell lung cancer (NSCLC) as well as their clinical prognostic significance. METHODS: Expression levels of ERCC1 were detected by IHC in 118 stage Ⅰ NSCLC patients. Kaplan-Meier survival curve, and Cox multivariate regression analysis were used for statistical analysis. RESULTS: The patients with high expression of ERCC1 had significantly longer survival time than those with low expression of ERCC1, and Cox multivariate regression analysis showed that expression of RRM1 was an independent prognostic factor for NSCLC patients. CONCLUSION: NSCLC patients with high ERCC1 expression have a better survival when compared to patients with low ERCC1 expression. Therefore, an intact DNA repair mechanism may reduce the accumulation of genetic aberrations that are thought to contribute to a tumor malignant potential and therefore the risk of relapse after definitive treatment.
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spelling pubmed-60007032018-07-06 ERCC1表达对Ⅰ期非小细胞肺癌患者术后生存率的影响 Zhongguo Fei Ai Za Zhi 临床研究 BACKGROUND AND OBJECTIVE: Proteins of the nucleotide excision repair pathway can repair DNA damage. The excision repair cross-complementing (ERCC) gene family reduce damagement of DNA by nucleotide excision and repair. The aim of this study is to investigate the expressions of ERCC1 (members of DNA repair gene family) in patients with non-small cell lung cancer (NSCLC) as well as their clinical prognostic significance. METHODS: Expression levels of ERCC1 were detected by IHC in 118 stage Ⅰ NSCLC patients. Kaplan-Meier survival curve, and Cox multivariate regression analysis were used for statistical analysis. RESULTS: The patients with high expression of ERCC1 had significantly longer survival time than those with low expression of ERCC1, and Cox multivariate regression analysis showed that expression of RRM1 was an independent prognostic factor for NSCLC patients. CONCLUSION: NSCLC patients with high ERCC1 expression have a better survival when compared to patients with low ERCC1 expression. Therefore, an intact DNA repair mechanism may reduce the accumulation of genetic aberrations that are thought to contribute to a tumor malignant potential and therefore the risk of relapse after definitive treatment. 中国肺癌杂志编辑部 2010-05-20 /pmc/articles/PMC6000703/ /pubmed/20677653 http://dx.doi.org/10.3779/j.issn.1009-3419.2010.05.26 Text en 版权所有©《中国肺癌杂志》编辑部2010 https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed in accordance with the terms of the Creative Commons Attribution (CC BY 3.0) License. See: https://creativecommons.org/licenses/by/3.0/
spellingShingle 临床研究
ERCC1表达对Ⅰ期非小细胞肺癌患者术后生存率的影响
title ERCC1表达对Ⅰ期非小细胞肺癌患者术后生存率的影响
title_full ERCC1表达对Ⅰ期非小细胞肺癌患者术后生存率的影响
title_fullStr ERCC1表达对Ⅰ期非小细胞肺癌患者术后生存率的影响
title_full_unstemmed ERCC1表达对Ⅰ期非小细胞肺癌患者术后生存率的影响
title_short ERCC1表达对Ⅰ期非小细胞肺癌患者术后生存率的影响
title_sort ercc1表达对ⅰ期非小细胞肺癌患者术后生存率的影响
topic 临床研究
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6000703/
https://www.ncbi.nlm.nih.gov/pubmed/20677653
http://dx.doi.org/10.3779/j.issn.1009-3419.2010.05.26
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