BET Inhibition Suppresses S100A8 and S100A9 Expression in Acute Myeloid Leukemia Cells and Synergises with Daunorubicin in Causing Cell Death

S100A8 and S100A9 are both members of the S100 family and have been shown to play roles in myeloid differentiation, autophagy, apoptosis, and chemotherapy resistance. In this study we demonstrate that the BET-bromodomain inhibitor JQ1 causes rapid suppression of S100A8 and S100A9 mRNA and protein in...

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Detalles Bibliográficos
Autores principales: Stewart, Helen J. S., Chaudry, Sabah, Crichlow, Asante, Luiling Feilding, Freya, Chevassut, Timothy J. T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6000862/
https://www.ncbi.nlm.nih.gov/pubmed/29955397
http://dx.doi.org/10.1155/2018/5742954

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