Chemerin is elevated in multiple myeloma patients and is expressed by stromal cells and pre-adipocytes

Chemerin is a recently discovered adipokine shown to be involved in both inflammatory and metabolic processes. Here, we demonstrate that chemerin serum levels are elevated in patients with multiple myeloma and that it increases with disease progression. We found that chemerin is expressed by stromal...

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Autores principales: Westhrin, Marita, Moen, Siv Helen, Kristensen, Ida Bruun, Buene, Glenn, Mylin, Anne Kærsgaard, Turesson, Ingemar, Abildgaard, Niels, Waage, Anders, Standal, Therese
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Letter to the Editor
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6001014/
https://www.ncbi.nlm.nih.gov/pubmed/29946468
http://dx.doi.org/10.1186/s40364-018-0134-y
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author Westhrin, Marita
Moen, Siv Helen
Kristensen, Ida Bruun
Buene, Glenn
Mylin, Anne Kærsgaard
Turesson, Ingemar
Abildgaard, Niels
Waage, Anders
Standal, Therese
author_facet Westhrin, Marita
Moen, Siv Helen
Kristensen, Ida Bruun
Buene, Glenn
Mylin, Anne Kærsgaard
Turesson, Ingemar
Abildgaard, Niels
Waage, Anders
Standal, Therese
author_sort Westhrin, Marita
collection PubMed
description Chemerin is a recently discovered adipokine shown to be involved in both inflammatory and metabolic processes. Here, we demonstrate that chemerin serum levels are elevated in patients with multiple myeloma and that it increases with disease progression. We found that chemerin is expressed by stromal cells and preadipocytes, whereas its receptor CCRL2 is expressed by primary myeloma cells, suggesting a paracrine signaling loop between bone marrow stromal cells/adipocytes and myeloma cells. This is the first study exploring chemerin and its receptors in multiple myeloma. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1186/s40364-018-0134-y) contains supplementary material, which is available to authorized users.
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spelling pubmed-60010142018-06-26 Chemerin is elevated in multiple myeloma patients and is expressed by stromal cells and pre-adipocytes Westhrin, Marita Moen, Siv Helen Kristensen, Ida Bruun Buene, Glenn Mylin, Anne Kærsgaard Turesson, Ingemar Abildgaard, Niels Waage, Anders Standal, Therese Biomark Res Letter to the Editor Chemerin is a recently discovered adipokine shown to be involved in both inflammatory and metabolic processes. Here, we demonstrate that chemerin serum levels are elevated in patients with multiple myeloma and that it increases with disease progression. We found that chemerin is expressed by stromal cells and preadipocytes, whereas its receptor CCRL2 is expressed by primary myeloma cells, suggesting a paracrine signaling loop between bone marrow stromal cells/adipocytes and myeloma cells. This is the first study exploring chemerin and its receptors in multiple myeloma. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1186/s40364-018-0134-y) contains supplementary material, which is available to authorized users. BioMed Central 2018-06-14 /pmc/articles/PMC6001014/ /pubmed/29946468 http://dx.doi.org/10.1186/s40364-018-0134-y Text en © The Author(s). 2018 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Letter to the Editor
Westhrin, Marita
Moen, Siv Helen
Kristensen, Ida Bruun
Buene, Glenn
Mylin, Anne Kærsgaard
Turesson, Ingemar
Abildgaard, Niels
Waage, Anders
Standal, Therese
Chemerin is elevated in multiple myeloma patients and is expressed by stromal cells and pre-adipocytes
title Chemerin is elevated in multiple myeloma patients and is expressed by stromal cells and pre-adipocytes
title_full Chemerin is elevated in multiple myeloma patients and is expressed by stromal cells and pre-adipocytes
title_fullStr Chemerin is elevated in multiple myeloma patients and is expressed by stromal cells and pre-adipocytes
title_full_unstemmed Chemerin is elevated in multiple myeloma patients and is expressed by stromal cells and pre-adipocytes
title_short Chemerin is elevated in multiple myeloma patients and is expressed by stromal cells and pre-adipocytes
title_sort chemerin is elevated in multiple myeloma patients and is expressed by stromal cells and pre-adipocytes
topic Letter to the Editor
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6001014/
https://www.ncbi.nlm.nih.gov/pubmed/29946468
http://dx.doi.org/10.1186/s40364-018-0134-y
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