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Development and validation of a multidimensional questionnaire for evaluating quality of life in melasma (HRQ-melasma)
BACKGROUND: Melasma has a major impact on quality of life. MELASQoL is the only validated specific psychometric instrument to evaluate melasma QoL. OBJECTIVE: To develop and validate a multidimensional questionnaire for evaluating quality of life related to facial melasma. METHODS: Cross-sectional s...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Sociedade Brasileira de Dermatologia
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6001090/ https://www.ncbi.nlm.nih.gov/pubmed/29924234 http://dx.doi.org/10.1590/abd1806-4841.20186780 |
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author | Pollo, Camila Fernandes Miot, Luciane Donida Bartoli Meneguin, Silmara Miot, Hélio Amante |
author_facet | Pollo, Camila Fernandes Miot, Luciane Donida Bartoli Meneguin, Silmara Miot, Hélio Amante |
author_sort | Pollo, Camila Fernandes |
collection | PubMed |
description | BACKGROUND: Melasma has a major impact on quality of life. MELASQoL is the only validated specific psychometric instrument to evaluate melasma QoL. OBJECTIVE: To develop and validate a multidimensional questionnaire for evaluating quality of life related to facial melasma. METHODS: Cross-sectional study performed in 2 institutions (public and private) from Brazil. Two focus groups were carried out: 5 board-certified dermatologists and 10 melasma patients, indicating the dimensions and significant units of melasma QoL. The preliminary questionnaire with 49 itens was applied to 154 facial melasma patients. Item reduction was performed by Rasch analysis. Parallel evaluations of clinical (MASI), demographic, and QoL aspects (MELASQoL, DLQI) were performed. The dimensional structure was assessed by confirmatory factor analysis. Temporal stability was tested in a subgroup of 42 individuals within 7-14 days. RESULTS: The mean (SD) age of the 154 interviewed subjects was 39±8 years, and 87% were females. The median (p25-p75) DLQI and MELASQoL were: 2 (1-6) and 30 (17-44). HRQ-Melasma consisted of 19 items distributed in 4 dimensions: Physical/Appearance, Social/Professional, Psychological, and Treatment. Cronbach’s alpha for HRQ-Melasma was 0.96, and >0.74 for each dimension. There was high correlation between HRQ-Melasma and DLQI and MELASQoL (rho=0.80 and 0.83), but modest with MASI (rho=0.35). Dimensional structure of HRQ-Melasma was stated by confirmatory factor analysis coefficients. Test-retest analysis disclosed an intraclass correlation coefficient of 0.91 (p<0.01). STUDY LIMITATIONS: Single-center study. CONCLUSIONS: A specific instrument to evaluate QoL in melasma with multidimensional characteristics was developed and validated, with appropriate psychometric performance. |
format | Online Article Text |
id | pubmed-6001090 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Sociedade Brasileira de Dermatologia |
record_format | MEDLINE/PubMed |
spelling | pubmed-60010902018-06-19 Development and validation of a multidimensional questionnaire for evaluating quality of life in melasma (HRQ-melasma) Pollo, Camila Fernandes Miot, Luciane Donida Bartoli Meneguin, Silmara Miot, Hélio Amante An Bras Dermatol Investigation BACKGROUND: Melasma has a major impact on quality of life. MELASQoL is the only validated specific psychometric instrument to evaluate melasma QoL. OBJECTIVE: To develop and validate a multidimensional questionnaire for evaluating quality of life related to facial melasma. METHODS: Cross-sectional study performed in 2 institutions (public and private) from Brazil. Two focus groups were carried out: 5 board-certified dermatologists and 10 melasma patients, indicating the dimensions and significant units of melasma QoL. The preliminary questionnaire with 49 itens was applied to 154 facial melasma patients. Item reduction was performed by Rasch analysis. Parallel evaluations of clinical (MASI), demographic, and QoL aspects (MELASQoL, DLQI) were performed. The dimensional structure was assessed by confirmatory factor analysis. Temporal stability was tested in a subgroup of 42 individuals within 7-14 days. RESULTS: The mean (SD) age of the 154 interviewed subjects was 39±8 years, and 87% were females. The median (p25-p75) DLQI and MELASQoL were: 2 (1-6) and 30 (17-44). HRQ-Melasma consisted of 19 items distributed in 4 dimensions: Physical/Appearance, Social/Professional, Psychological, and Treatment. Cronbach’s alpha for HRQ-Melasma was 0.96, and >0.74 for each dimension. There was high correlation between HRQ-Melasma and DLQI and MELASQoL (rho=0.80 and 0.83), but modest with MASI (rho=0.35). Dimensional structure of HRQ-Melasma was stated by confirmatory factor analysis coefficients. Test-retest analysis disclosed an intraclass correlation coefficient of 0.91 (p<0.01). STUDY LIMITATIONS: Single-center study. CONCLUSIONS: A specific instrument to evaluate QoL in melasma with multidimensional characteristics was developed and validated, with appropriate psychometric performance. Sociedade Brasileira de Dermatologia 2018 /pmc/articles/PMC6001090/ /pubmed/29924234 http://dx.doi.org/10.1590/abd1806-4841.20186780 Text en http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivative License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium provided the original work is properly cited and the work is not changed in any way. |
spellingShingle | Investigation Pollo, Camila Fernandes Miot, Luciane Donida Bartoli Meneguin, Silmara Miot, Hélio Amante Development and validation of a multidimensional questionnaire for evaluating quality of life in melasma (HRQ-melasma) |
title | Development and validation of a multidimensional questionnaire for
evaluating quality of life in melasma (HRQ-melasma) |
title_full | Development and validation of a multidimensional questionnaire for
evaluating quality of life in melasma (HRQ-melasma) |
title_fullStr | Development and validation of a multidimensional questionnaire for
evaluating quality of life in melasma (HRQ-melasma) |
title_full_unstemmed | Development and validation of a multidimensional questionnaire for
evaluating quality of life in melasma (HRQ-melasma) |
title_short | Development and validation of a multidimensional questionnaire for
evaluating quality of life in melasma (HRQ-melasma) |
title_sort | development and validation of a multidimensional questionnaire for
evaluating quality of life in melasma (hrq-melasma) |
topic | Investigation |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6001090/ https://www.ncbi.nlm.nih.gov/pubmed/29924234 http://dx.doi.org/10.1590/abd1806-4841.20186780 |
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