Cargando…

Liver transplant score for prediction of biliary atresia patients’ survival following Kasai procedure

OBJECTIVES: Recently, a scoring system has been developed to predict which patients with biliary atresia (BA) who underwent a Kasai procedure should be considered for liver transplant. Here, we applied the scoring system to predict the survival of BA patients following the Kasai procedure at Dr. Sar...

Descripción completa

Detalles Bibliográficos
Autores principales: Gunadi, Gunawan, Timotheus Allen, Widiyanto, Galih, Yuanita, Amalia, Mulyani, Nenny Sri, Makhmudi, Akhmad
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6001125/
https://www.ncbi.nlm.nih.gov/pubmed/29898778
http://dx.doi.org/10.1186/s13104-018-3498-z
_version_ 1783331922282283008
author Gunadi
Gunawan, Timotheus Allen
Widiyanto, Galih
Yuanita, Amalia
Mulyani, Nenny Sri
Makhmudi, Akhmad
author_facet Gunadi
Gunawan, Timotheus Allen
Widiyanto, Galih
Yuanita, Amalia
Mulyani, Nenny Sri
Makhmudi, Akhmad
author_sort Gunadi
collection PubMed
description OBJECTIVES: Recently, a scoring system has been developed to predict which patients with biliary atresia (BA) who underwent a Kasai procedure should be considered for liver transplant. Here, we applied the scoring system to predict the survival of BA patients following the Kasai procedure at Dr. Sardjito Hospital, Yogyakarta, Indonesia from January 2012 to January 2016. RESULTS: There were 26 patients, of whom 14 were males and 12 females. Outcomes of BA patients after the Kasai surgery were 15 survived and 11 died. There were significant associations between ascites and sepsis with the liver transplant score of ≥ 8 (p value = 0.006 and 0.014, respectively), whereas post-operative bilirubin level, ALT level, prothrombin time, cirrhosis, esophageal varices, portal hypertension, and cholangitis did not significantly correlate to the score. The patients with a score ≥ 8 have a relatively greater risk by 3.5-fold to die compared with patients with a score < 8, but it did not reach a significant level (p value = 0.13). In conclusions, the incidence of ascites and sepsis might predict the poor prognosis of BA patients following the Kasai procedure. Moreover, patients with a score ≥ 8 are prone to die after the Kasai surgery if they do not undergo a liver transplant.
format Online
Article
Text
id pubmed-6001125
institution National Center for Biotechnology Information
language English
publishDate 2018
publisher BioMed Central
record_format MEDLINE/PubMed
spelling pubmed-60011252018-06-26 Liver transplant score for prediction of biliary atresia patients’ survival following Kasai procedure Gunadi Gunawan, Timotheus Allen Widiyanto, Galih Yuanita, Amalia Mulyani, Nenny Sri Makhmudi, Akhmad BMC Res Notes Research Note OBJECTIVES: Recently, a scoring system has been developed to predict which patients with biliary atresia (BA) who underwent a Kasai procedure should be considered for liver transplant. Here, we applied the scoring system to predict the survival of BA patients following the Kasai procedure at Dr. Sardjito Hospital, Yogyakarta, Indonesia from January 2012 to January 2016. RESULTS: There were 26 patients, of whom 14 were males and 12 females. Outcomes of BA patients after the Kasai surgery were 15 survived and 11 died. There were significant associations between ascites and sepsis with the liver transplant score of ≥ 8 (p value = 0.006 and 0.014, respectively), whereas post-operative bilirubin level, ALT level, prothrombin time, cirrhosis, esophageal varices, portal hypertension, and cholangitis did not significantly correlate to the score. The patients with a score ≥ 8 have a relatively greater risk by 3.5-fold to die compared with patients with a score < 8, but it did not reach a significant level (p value = 0.13). In conclusions, the incidence of ascites and sepsis might predict the poor prognosis of BA patients following the Kasai procedure. Moreover, patients with a score ≥ 8 are prone to die after the Kasai surgery if they do not undergo a liver transplant. BioMed Central 2018-06-13 /pmc/articles/PMC6001125/ /pubmed/29898778 http://dx.doi.org/10.1186/s13104-018-3498-z Text en © The Author(s) 2018 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research Note
Gunadi
Gunawan, Timotheus Allen
Widiyanto, Galih
Yuanita, Amalia
Mulyani, Nenny Sri
Makhmudi, Akhmad
Liver transplant score for prediction of biliary atresia patients’ survival following Kasai procedure
title Liver transplant score for prediction of biliary atresia patients’ survival following Kasai procedure
title_full Liver transplant score for prediction of biliary atresia patients’ survival following Kasai procedure
title_fullStr Liver transplant score for prediction of biliary atresia patients’ survival following Kasai procedure
title_full_unstemmed Liver transplant score for prediction of biliary atresia patients’ survival following Kasai procedure
title_short Liver transplant score for prediction of biliary atresia patients’ survival following Kasai procedure
title_sort liver transplant score for prediction of biliary atresia patients’ survival following kasai procedure
topic Research Note
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6001125/
https://www.ncbi.nlm.nih.gov/pubmed/29898778
http://dx.doi.org/10.1186/s13104-018-3498-z
work_keys_str_mv AT gunadi livertransplantscoreforpredictionofbiliaryatresiapatientssurvivalfollowingkasaiprocedure
AT gunawantimotheusallen livertransplantscoreforpredictionofbiliaryatresiapatientssurvivalfollowingkasaiprocedure
AT widiyantogalih livertransplantscoreforpredictionofbiliaryatresiapatientssurvivalfollowingkasaiprocedure
AT yuanitaamalia livertransplantscoreforpredictionofbiliaryatresiapatientssurvivalfollowingkasaiprocedure
AT mulyaninennysri livertransplantscoreforpredictionofbiliaryatresiapatientssurvivalfollowingkasaiprocedure
AT makhmudiakhmad livertransplantscoreforpredictionofbiliaryatresiapatientssurvivalfollowingkasaiprocedure