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Liver transplant score for prediction of biliary atresia patients’ survival following Kasai procedure
OBJECTIVES: Recently, a scoring system has been developed to predict which patients with biliary atresia (BA) who underwent a Kasai procedure should be considered for liver transplant. Here, we applied the scoring system to predict the survival of BA patients following the Kasai procedure at Dr. Sar...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6001125/ https://www.ncbi.nlm.nih.gov/pubmed/29898778 http://dx.doi.org/10.1186/s13104-018-3498-z |
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author | Gunadi Gunawan, Timotheus Allen Widiyanto, Galih Yuanita, Amalia Mulyani, Nenny Sri Makhmudi, Akhmad |
author_facet | Gunadi Gunawan, Timotheus Allen Widiyanto, Galih Yuanita, Amalia Mulyani, Nenny Sri Makhmudi, Akhmad |
author_sort | Gunadi |
collection | PubMed |
description | OBJECTIVES: Recently, a scoring system has been developed to predict which patients with biliary atresia (BA) who underwent a Kasai procedure should be considered for liver transplant. Here, we applied the scoring system to predict the survival of BA patients following the Kasai procedure at Dr. Sardjito Hospital, Yogyakarta, Indonesia from January 2012 to January 2016. RESULTS: There were 26 patients, of whom 14 were males and 12 females. Outcomes of BA patients after the Kasai surgery were 15 survived and 11 died. There were significant associations between ascites and sepsis with the liver transplant score of ≥ 8 (p value = 0.006 and 0.014, respectively), whereas post-operative bilirubin level, ALT level, prothrombin time, cirrhosis, esophageal varices, portal hypertension, and cholangitis did not significantly correlate to the score. The patients with a score ≥ 8 have a relatively greater risk by 3.5-fold to die compared with patients with a score < 8, but it did not reach a significant level (p value = 0.13). In conclusions, the incidence of ascites and sepsis might predict the poor prognosis of BA patients following the Kasai procedure. Moreover, patients with a score ≥ 8 are prone to die after the Kasai surgery if they do not undergo a liver transplant. |
format | Online Article Text |
id | pubmed-6001125 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-60011252018-06-26 Liver transplant score for prediction of biliary atresia patients’ survival following Kasai procedure Gunadi Gunawan, Timotheus Allen Widiyanto, Galih Yuanita, Amalia Mulyani, Nenny Sri Makhmudi, Akhmad BMC Res Notes Research Note OBJECTIVES: Recently, a scoring system has been developed to predict which patients with biliary atresia (BA) who underwent a Kasai procedure should be considered for liver transplant. Here, we applied the scoring system to predict the survival of BA patients following the Kasai procedure at Dr. Sardjito Hospital, Yogyakarta, Indonesia from January 2012 to January 2016. RESULTS: There were 26 patients, of whom 14 were males and 12 females. Outcomes of BA patients after the Kasai surgery were 15 survived and 11 died. There were significant associations between ascites and sepsis with the liver transplant score of ≥ 8 (p value = 0.006 and 0.014, respectively), whereas post-operative bilirubin level, ALT level, prothrombin time, cirrhosis, esophageal varices, portal hypertension, and cholangitis did not significantly correlate to the score. The patients with a score ≥ 8 have a relatively greater risk by 3.5-fold to die compared with patients with a score < 8, but it did not reach a significant level (p value = 0.13). In conclusions, the incidence of ascites and sepsis might predict the poor prognosis of BA patients following the Kasai procedure. Moreover, patients with a score ≥ 8 are prone to die after the Kasai surgery if they do not undergo a liver transplant. BioMed Central 2018-06-13 /pmc/articles/PMC6001125/ /pubmed/29898778 http://dx.doi.org/10.1186/s13104-018-3498-z Text en © The Author(s) 2018 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Research Note Gunadi Gunawan, Timotheus Allen Widiyanto, Galih Yuanita, Amalia Mulyani, Nenny Sri Makhmudi, Akhmad Liver transplant score for prediction of biliary atresia patients’ survival following Kasai procedure |
title | Liver transplant score for prediction of biliary atresia patients’ survival following Kasai procedure |
title_full | Liver transplant score for prediction of biliary atresia patients’ survival following Kasai procedure |
title_fullStr | Liver transplant score for prediction of biliary atresia patients’ survival following Kasai procedure |
title_full_unstemmed | Liver transplant score for prediction of biliary atresia patients’ survival following Kasai procedure |
title_short | Liver transplant score for prediction of biliary atresia patients’ survival following Kasai procedure |
title_sort | liver transplant score for prediction of biliary atresia patients’ survival following kasai procedure |
topic | Research Note |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6001125/ https://www.ncbi.nlm.nih.gov/pubmed/29898778 http://dx.doi.org/10.1186/s13104-018-3498-z |
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