Iterative Chemical Engineering of Vancomycin Leads to Novel Vancomycin Analogs With a High in Vitro Therapeutic Index

Vancomycin is a glycopeptide antibiotic that inhibits transpeptidation during cell wall synthesis by binding to the D-Ala-D-Ala termini of lipid II. For long, it has been used as a last resort antibiotic. However, since the emergence of the first vancomycin-resistant enterococci in 1987, vancomycin...

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Detalles Bibliográficos
Autores principales: Mishra, Nigam M., Stolarzewicz, Izabela, Cannaerts, David, Schuermans, Joris, Lavigne, Rob, Looz, Yannick, Landuyt, Bart, Schoofs, Liliane, Schols, Dominique, Paeshuyse, Jan, Hickenbotham, Peter, Clokie, Martha, Luyten, Walter, Van der Eycken, Erik V., Briers, Yves
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Microbiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6001238/
https://www.ncbi.nlm.nih.gov/pubmed/29930540
http://dx.doi.org/10.3389/fmicb.2018.01175

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