Skeletal muscle O-GlcNAc transferase is important for muscle energy homeostasis and whole-body insulin sensitivity

OBJECTIVE: Given that cellular O-GlcNAcylation levels are thought to be real-time measures of cellular nutrient status and dysregulated O-GlcNAc signaling is associated with insulin resistance, we evaluated the role of O-GlcNAc transferase (OGT), the enzyme that mediates O-GlcNAcylation, in skeletal...

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Detalles Bibliográficos
Autores principales: Shi, Hao, Munk, Alexander, Nielsen, Thomas S., Daughtry, Morgan R., Larsson, Louise, Li, Shize, Høyer, Kasper F., Geisler, Hannah W., Sulek, Karolina, Kjøbsted, Rasmus, Fisher, Taylor, Andersen, Marianne M., Shen, Zhengxing, Hansen, Ulrik K., England, Eric M., Cheng, Zhiyong, Højlund, Kurt, Wojtaszewski, Jørgen F.P., Yang, Xiaoyong, Hulver, Matthew W., Helm, Richard F., Treebak, Jonas T., Gerrard, David E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2018
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6001359/
https://www.ncbi.nlm.nih.gov/pubmed/29525407
http://dx.doi.org/10.1016/j.molmet.2018.02.010

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