Adipocyte Xbp1s overexpression drives uridine production and reduces obesity

OBJECTIVE: The spliced transcription factor Xbp1 (Xbp1s), a transducer of the unfolded protein response (UPR), regulates lipolysis. Lipolysis is stimulated by fasting when uridine synthesis is also activated in adipocytes. METHODS: Here we have examined the regulatory role Xbp1s in stimulation of ur...

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Detalles Bibliográficos
Autores principales: Deng, Yingfeng, Wang, Zhao V., Gordillo, Ruth, Zhu, Yi, Ali, Aktar, Zhang, Chen, Wang, Xiaoding, Shao, Mengle, Zhang, Zhuzhen, Iyengar, Puneeth, Gupta, Rana K., Horton, Jay D., Hill, Joseph A., Scherer, Philipp E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2018
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6001360/
https://www.ncbi.nlm.nih.gov/pubmed/29551634
http://dx.doi.org/10.1016/j.molmet.2018.02.013

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