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Neural stem cell quiescence and stemness are molecularly distinct outputs of the Notch3 signalling cascade in the vertebrate adult brain

Neural stem cells (NSCs) in the adult vertebrate brain are found in a quiescent state and can preserve long-lasting progenitor potential (stemness). Whether and how these two properties are linked, and to what extent they can be independently controlled by NSC maintenance pathways, is unresolved. We...

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Detalles Bibliográficos
Autores principales: Than-Trong, Emmanuel, Ortica-Gatti, Sara, Mella, Sébastien, Nepal, Chirag, Alunni, Alessandro, Bally-Cuif, Laure
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists Ltd 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6001379/
https://www.ncbi.nlm.nih.gov/pubmed/29695612
http://dx.doi.org/10.1242/dev.161034