Growth hormone receptor-deficient pigs resemble the pathophysiology of human Laron syndrome and reveal altered activation of signaling cascades in the liver

OBJECTIVE: Laron syndrome (LS) is a rare, autosomal recessive disorder in humans caused by loss-of-function mutations of the growth hormone receptor (GHR) gene. To establish a large animal model for LS, pigs with GHR knockout (KO) mutations were generated and characterized. METHODS: CRISPR/Cas9 tech...

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Detalles Bibliográficos
Autores principales: Hinrichs, Arne, Kessler, Barbara, Kurome, Mayuko, Blutke, Andreas, Kemter, Elisabeth, Bernau, Maren, Scholz, Armin M., Rathkolb, Birgit, Renner, Simone, Bultmann, Sebastian, Leonhardt, Heinrich, de Angelis, Martin Hrabĕ, Nagashima, Hiroshi, Hoeflich, Andreas, Blum, Werner F., Bidlingmaier, Martin, Wanke, Rüdiger, Dahlhoff, Maik, Wolf, Eckhard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2018
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6001387/
https://www.ncbi.nlm.nih.gov/pubmed/29678421
http://dx.doi.org/10.1016/j.molmet.2018.03.006

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