Using (2)H labelling to improve the NMR detectability of pyridine and its derivatives by SABRE

By introducing a range of (2)H labels into pyridine and the para‐substituted agents, methyl isonicotinate and isonicotinamide, we significantly improve their NMR detectability in conjunction with the signal amplification by reversible exchange process. We describe how the rates of T (1) relaxation f...

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Detalles Bibliográficos
Autores principales: Norcott, Philip, Burns, Michael J., Rayner, Peter J., Mewis, Ryan E., Duckett, Simon B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Special Issue Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6001449/
https://www.ncbi.nlm.nih.gov/pubmed/29274294
http://dx.doi.org/10.1002/mrc.4703
Descripción
Sumario:By introducing a range of (2)H labels into pyridine and the para‐substituted agents, methyl isonicotinate and isonicotinamide, we significantly improve their NMR detectability in conjunction with the signal amplification by reversible exchange process. We describe how the rates of T (1) relaxation for the remaining (1)H nuclei are increased and show how this leads to a concomitant increase in the level of (1)H and (13)C hyperpolarization that can ultimately be detected.

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