Using (2)H labelling to improve the NMR detectability of pyridine and its derivatives by SABRE

By introducing a range of (2)H labels into pyridine and the para‐substituted agents, methyl isonicotinate and isonicotinamide, we significantly improve their NMR detectability in conjunction with the signal amplification by reversible exchange process. We describe how the rates of T (1) relaxation f...

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Autores principales: Norcott, Philip, Burns, Michael J., Rayner, Peter J., Mewis, Ryan E., Duckett, Simon B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Special Issue Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6001449/
https://www.ncbi.nlm.nih.gov/pubmed/29274294
http://dx.doi.org/10.1002/mrc.4703
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author Norcott, Philip
Burns, Michael J.
Rayner, Peter J.
Mewis, Ryan E.
Duckett, Simon B.
author_facet Norcott, Philip
Burns, Michael J.
Rayner, Peter J.
Mewis, Ryan E.
Duckett, Simon B.
author_sort Norcott, Philip
collection PubMed
description By introducing a range of (2)H labels into pyridine and the para‐substituted agents, methyl isonicotinate and isonicotinamide, we significantly improve their NMR detectability in conjunction with the signal amplification by reversible exchange process. We describe how the rates of T (1) relaxation for the remaining (1)H nuclei are increased and show how this leads to a concomitant increase in the level of (1)H and (13)C hyperpolarization that can ultimately be detected.
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spelling pubmed-60014492018-06-21 Using (2)H labelling to improve the NMR detectability of pyridine and its derivatives by SABRE Norcott, Philip Burns, Michael J. Rayner, Peter J. Mewis, Ryan E. Duckett, Simon B. Magn Reson Chem Special Issue Research Articles By introducing a range of (2)H labels into pyridine and the para‐substituted agents, methyl isonicotinate and isonicotinamide, we significantly improve their NMR detectability in conjunction with the signal amplification by reversible exchange process. We describe how the rates of T (1) relaxation for the remaining (1)H nuclei are increased and show how this leads to a concomitant increase in the level of (1)H and (13)C hyperpolarization that can ultimately be detected. John Wiley and Sons Inc. 2018-01-25 2018-07 /pmc/articles/PMC6001449/ /pubmed/29274294 http://dx.doi.org/10.1002/mrc.4703 Text en © 2017 The Authors. Magnetic Resonance in Chemistry published by John Wiley & Sons Ltd. This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Special Issue Research Articles
Norcott, Philip
Burns, Michael J.
Rayner, Peter J.
Mewis, Ryan E.
Duckett, Simon B.
Using (2)H labelling to improve the NMR detectability of pyridine and its derivatives by SABRE
title Using (2)H labelling to improve the NMR detectability of pyridine and its derivatives by SABRE
title_full Using (2)H labelling to improve the NMR detectability of pyridine and its derivatives by SABRE
title_fullStr Using (2)H labelling to improve the NMR detectability of pyridine and its derivatives by SABRE
title_full_unstemmed Using (2)H labelling to improve the NMR detectability of pyridine and its derivatives by SABRE
title_short Using (2)H labelling to improve the NMR detectability of pyridine and its derivatives by SABRE
title_sort using (2)h labelling to improve the nmr detectability of pyridine and its derivatives by sabre
topic Special Issue Research Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6001449/
https://www.ncbi.nlm.nih.gov/pubmed/29274294
http://dx.doi.org/10.1002/mrc.4703
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