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Aire controls the recirculation of murine Foxp3(+) regulatory T‐cells back to the thymus

In the thymus, medullary thymic epithelial cells (mTEC) determine the fate of newly selected CD4(+) and CD8(+) single positive (SP) thymocytes. For example, mTEC expression of Aire controls intrathymic self‐antigen availability for negative selection. Interestingly, alterations in both Foxp3(+) Regu...

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Detalles Bibliográficos
Autores principales:	Cowan, Jennifer E., Baik, Song, McCarthy, Nicholas I., Parnell, Sonia M., White, Andrea J., Jenkinson, William E., Anderson, Graham
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2018
Materias:	Leukocyte and lymphoid organ ontogeny
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6001551/ https://www.ncbi.nlm.nih.gov/pubmed/29285761 http://dx.doi.org/10.1002/eji.201747375

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