Health risks associated with genetic alterations in internal clock system by external factors

The circadian system maintains the main aspects of physiological and behavioral processes. Both circadian rhythm and sleep impact an organism's health through interaction with environmental factors. Variations in external factors influence the functionality of clock genes and disrupt 24-hour rh...

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Autores principales: Khan, Suliman, Nabi, Ghulam, Yao, Lunguang, Siddique, Rabeea, Sajjad, Wasim, Kumar, Sunjeet, Duan, Pengfei, Hou, Hongwei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2018
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6001675/
https://www.ncbi.nlm.nih.gov/pubmed/29910689
http://dx.doi.org/10.7150/ijbs.23744
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author Khan, Suliman
Nabi, Ghulam
Yao, Lunguang
Siddique, Rabeea
Sajjad, Wasim
Kumar, Sunjeet
Duan, Pengfei
Hou, Hongwei
author_facet Khan, Suliman
Nabi, Ghulam
Yao, Lunguang
Siddique, Rabeea
Sajjad, Wasim
Kumar, Sunjeet
Duan, Pengfei
Hou, Hongwei
author_sort Khan, Suliman
collection PubMed
description The circadian system maintains the main aspects of physiological and behavioral processes. Both circadian rhythm and sleep impact an organism's health through interaction with environmental factors. Variations in external factors influence the functionality of clock genes and disrupt 24-hour rhythmic cycle. The disrupted circadian rhythm and disregulated sleep affect an organism's health, thereby causing several disorders including cancer, depression and cardiac disorders. Considering the role of clock genes and environmental factors, extensive investigation is required focusing on pathways involved in development of life-threatening disorders. This review identifies the major risks and associated factors related with disruption in circadian system and sleep.
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spelling pubmed-60016752018-06-15 Health risks associated with genetic alterations in internal clock system by external factors Khan, Suliman Nabi, Ghulam Yao, Lunguang Siddique, Rabeea Sajjad, Wasim Kumar, Sunjeet Duan, Pengfei Hou, Hongwei Int J Biol Sci Review The circadian system maintains the main aspects of physiological and behavioral processes. Both circadian rhythm and sleep impact an organism's health through interaction with environmental factors. Variations in external factors influence the functionality of clock genes and disrupt 24-hour rhythmic cycle. The disrupted circadian rhythm and disregulated sleep affect an organism's health, thereby causing several disorders including cancer, depression and cardiac disorders. Considering the role of clock genes and environmental factors, extensive investigation is required focusing on pathways involved in development of life-threatening disorders. This review identifies the major risks and associated factors related with disruption in circadian system and sleep. Ivyspring International Publisher 2018-05-21 /pmc/articles/PMC6001675/ /pubmed/29910689 http://dx.doi.org/10.7150/ijbs.23744 Text en © Ivyspring International Publisher This is an open access article distributed under the terms of the Creative Commons Attribution (CC BY-NC) license (https://creativecommons.org/licenses/by-nc/4.0/). See http://ivyspring.com/terms for full terms and conditions.
spellingShingle Review
Khan, Suliman
Nabi, Ghulam
Yao, Lunguang
Siddique, Rabeea
Sajjad, Wasim
Kumar, Sunjeet
Duan, Pengfei
Hou, Hongwei
Health risks associated with genetic alterations in internal clock system by external factors
title Health risks associated with genetic alterations in internal clock system by external factors
title_full Health risks associated with genetic alterations in internal clock system by external factors
title_fullStr Health risks associated with genetic alterations in internal clock system by external factors
title_full_unstemmed Health risks associated with genetic alterations in internal clock system by external factors
title_short Health risks associated with genetic alterations in internal clock system by external factors
title_sort health risks associated with genetic alterations in internal clock system by external factors
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6001675/
https://www.ncbi.nlm.nih.gov/pubmed/29910689
http://dx.doi.org/10.7150/ijbs.23744
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