A dual-specific IGF-I/II human engineered antibody domain inhibits IGF signaling in breast cancer cells

The insulin-like growth factors (IGFs), IGF-I and IGF-II, are essential for regulating cell growth, differentiation and metastasis of a broad range of malignancies. The IGF-I/II actions are mediated through the IGF receptor type 1 (IGF-1R) and the insulin receptor (IR), which are overexpressed in mu...

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Detalles Bibliográficos
Autores principales: Chen, Zhizhen, Liu, Jie, Chu, Dafeng, Shan, Yaming, Ma, Guixing, Zhang, Hongmin, Zhang, Xiaohua Douglas, Wang, Pu, Chen, Qiang, Deng, Chuxia, Chen, Weizao, Dimitrov, Dimiter S., Zhao, Qi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2018
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6001679/
https://www.ncbi.nlm.nih.gov/pubmed/29910690
http://dx.doi.org/10.7150/ijbs.25928

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