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Exploration of Strategies for Mechanism‐Based Inhibitor Design for Family GH99 endo‐α‐1,2‐Mannanases

endo‐α‐1,2‐Mannosidases and ‐mannanases, members of glycoside hydrolase family 99 (GH99), cleave α‐Glc/Man‐1,3‐α‐Man‐OR structures within mammalian N‐linked glycans and fungal α‐mannan, respectively. They are proposed to act through a two‐step mechanism involving a 1,2‐anhydrosugar “epoxide” interme...

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Detalles Bibliográficos
Autores principales:	Fernandes, Pearl Z., Petricevic, Marija, Sobala, Lukasz, Davies, Gideon J., Williams, Spencer J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2018
Materias:	Full Papers
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6001782/ https://www.ncbi.nlm.nih.gov/pubmed/29508463 http://dx.doi.org/10.1002/chem.201800435

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