Delivery of an anti‐transthyretin Nanobody to the brain through intranasal administration reveals transthyretin expression and secretion by motor neurons

Transthyretin (TTR) is a transport protein of retinol and thyroxine in serum and CSF, which is mainly secreted by liver and choroid plexus, and in smaller amounts in other cells throughout the body. The exact role of TTR and its specific expression in Central Nervous System (CNS) remains understudie...

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Detalles Bibliográficos
Autores principales: Gomes, João R., Cabrito, Inês, Soares, Hugo R., Costelha, Susete, Teixeira, Anabela, Wittelsberger, Angela, Stortelers, Catelijne, Vanlandschoot, Peter, Saraiva, Maria J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
ORIGINAL ARTICLES
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6001800/
https://www.ncbi.nlm.nih.gov/pubmed/29527688
http://dx.doi.org/10.1111/jnc.14332

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6001800/
https://www.ncbi.nlm.nih.gov/pubmed/29527688
http://dx.doi.org/10.1111/jnc.14332

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