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Targeting hepatic pyruvate dehydrogenase kinases restores insulin signaling and mitigates ChREBP-mediated lipogenesis in diet-induced obese mice

OBJECTIVE: Mitochondrial pyruvate dehydrogenase kinases 1–4 (PDKs1–4) negatively regulate activity of the pyruvate dehydrogenase complex (PDC) by reversible phosphorylation. PDKs play a pivotal role in maintaining energy homeostasis and contribute to metabolic flexibility by attenuating PDC activity...

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Detalles Bibliográficos
Autores principales:	Wu, Cheng-Yang, Tso, Shih-Chia, Chuang, Jacinta L., Gui, Wen-Jun, Lou, Mingliang, Sharma, Gaurav, Khemtong, Chalermchai, Qi, Xiangbing, Wynn, R. Max, Chuang, David T.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2018
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6001905/ https://www.ncbi.nlm.nih.gov/pubmed/29656110 http://dx.doi.org/10.1016/j.molmet.2018.03.014

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