Cargando…

mTORC1-dependent increase in oxidative metabolism in POMC neurons regulates food intake and action of leptin

OBJECTIVE: Nutrient availability modulates reactive oxygen species (ROS) production in the hypothalamus. In turn, ROS regulate hypothalamic neuronal activity and feeding behavior. The mechanistic target of rapamycin complex 1 (mTORC1) pathway is an important cellular integrator of the action of nutr...

Descripción completa

Detalles Bibliográficos
Autores principales:	Haissaguerre, Magalie, Ferrière, Amandine, Simon, Vincent, Saucisse, Nicolas, Dupuy, Nathalie, André, Caroline, Clark, Samantha, Guzman-Quevedo, Omar, Tabarin, Antoine, Cota, Daniela
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2018
Materias:	Brief Communication
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6001919/ https://www.ncbi.nlm.nih.gov/pubmed/29699927 http://dx.doi.org/10.1016/j.molmet.2018.04.002

Ejemplares similares

NPV-BSK805, an Antineoplastic Jak2 Inhibitor Effective in Myeloproliferative Disorders, Causes Adiposity in Mice by Interfering With the Action of Leptin
por: Haissaguerre, Magalie, et al.
Publicado: (2018)

The cannabinoid CB(1) receptor and mTORC1 signalling pathways interact to modulate glucose homeostasis in mice
por: Bermudez-Silva, Francisco J., et al.
Publicado: (2016)

mTORC1 and CB1 receptor signaling regulate excitatory glutamatergic inputs onto the hypothalamic paraventricular nucleus in response to energy availability
por: Mazier, Wilfrid, et al.
Publicado: (2019)

mTORC1 and mTORC2 in cancer and the tumor microenvironment
por: Kim, Laura C., et al.
Publicado: (2016)

Pathogenic Role of mTORC1 and mTORC2 in Pulmonary Hypertension
por: Tang, Haiyang, et al.
Publicado: (2018)

mTORC2, the “other” mTOR, is a new player in energy balance regulation
por: Cota, Daniela
Publicado: (2014)

Both mTORC1 and mTORC2 are involved in the regulation of cell adhesion
por: Chen, Long, et al.
Publicado: (2015)

The metabolic waste ammonium regulates mTORC2 and mTORC1 signaling
por: Merhi, Ahmad, et al.
Publicado: (2017)

Adiponectin potentiates the acute effects of leptin in arcuate Pomc neurons
por: Sun, Jia, et al.
Publicado: (2016)

Dietary restriction protects against experimental cerebral malaria via leptin modulation and T cell mTORC1 suppression
por: Mejia, Pedro, et al.
Publicado: (2015)

mTORC1 and mTORC2 regulate skin morphogenesis and epidermal barrier formation
por: Ding, Xiaolei, et al.
Publicado: (2016)

LPS Induces mTORC1 and mTORC2 Activation During Monocyte Adhesion
por: Ribeiro, Marcelle C., et al.
Publicado: (2018)

mTORC1 and mTORC2 differentially promote natural killer cell development
por: Yang, Chao, et al.
Publicado: (2018)

mTORC1 and mTORC2 are differentially engaged in the development of laser-induced CNV
por: Yang, Jin Young, et al.
Publicado: (2019)

Dopamine neuron morphology and output are differentially controlled by mTORC1 and mTORC2
por: Kosillo, Polina, et al.
Publicado: (2022)

Brain-specific inhibition of mTORC1 eliminates side effects resulting from mTORC1 blockade in the periphery and reduces alcohol intake in mice
por: Ehinger, Yann, et al.
Publicado: (2021)

Impaired quality of life, but not cognition, is linked to a history of chronic hypercortisolism in patients with Cushing’s disease in remission
por: Pupier, Emilie, et al.
Publicado: (2022)

Rapamycin inhibits mSin1 phosphorylation independently of mTORC1 and mTORC2
por: Luo, Yan, et al.
Publicado: (2015)

Regulation of Autophagy through TORC1 and mTORC1
por: Noda, Takeshi
Publicado: (2017)

Pasireotide-LAR in acromegaly patients treated with a combination therapy: a real-life study
por: Lasolle, Hélène, et al.
Publicado: (2019)

POMC neurons expressing leptin receptors coordinate metabolic responses to fasting via suppression of leptin levels
por: Caron, Alexandre, et al.
Publicado: (2018)

Glutaminolysis feeds mTORC1
por: Durán, Raúl V., et al.
Publicado: (2012)

Regulation of adiposity by mTORC1
por: Magdalon, Juliana, et al.
Publicado: (2017)

Regulation of mTORC2 Signaling
por: Fu, Wenxiang, et al.
Publicado: (2020)

mTORC2 Steals the Spotlight
por: Jansen, Laura A.
Publicado: (2020)

Something to mTORC About in NASH
por: Finck, Brian N.
Publicado: (2022)

mTORC2, but not mTORC1, is required for hippocampal mGluR-LTD and associated behaviors
por: Zhu, Ping Jun, et al.
Publicado: (2018)

Leptin is required for hypothalamic regulation of miRNAs targeting POMC 3′UTR
por: Derghal, Adel, et al.
Publicado: (2015)

Olanzapine- induced metabolic syndrome pathogenesis: Hypothalamic “leptin resistance” or “pomc resistance”?
por: Veneziani, F., et al.
Publicado: (2021)

Active-Site Inhibitors of mTOR Target Rapamycin-Resistant Outputs of mTORC1 and mTORC2
por: Feldman, Morris E, et al.
Publicado: (2009)

Influenza virus differentially activates mTORC1 and mTORC2 signaling to maximize late stage replication
por: Kuss-Duerkop, Sharon K., et al.
Publicado: (2017)

Differential regulation of mTORC1 and mTORC2 is critical for 8-Br-cAMP-induced decidualization
por: Baek, Mi-Ock, et al.
Publicado: (2018)

Genetic inactivation of mTORC1 or mTORC2 in neurons reveals distinct functions in glutamatergic synaptic transmission
por: McCabe, Matthew P, et al.
Publicado: (2020)

LATS suppresses mTORC1 activity to directly coordinate Hippo and mTORC1 pathways in growth control
por: Gan, Wenjian, et al.
Publicado: (2020)

Hyperactivity of mTORC1 or mTORC2-dependent signaling causes epilepsy downstream of somatic PTEN loss
por: Cullen, Erin R., et al.
Publicado: (2023)

Dynamics of mTORC1 activation in response to amino acids
por: Manifava, Maria, et al.
Publicado: (2016)

An expanded role for mTORC1 in autophagy
por: Kim, Young-Mi, et al.
Publicado: (2015)

mTORC1 as the main gateway to autophagy
por: Rabanal-Ruiz, Yoana, et al.
Publicado: (2017)

Towards specific inhibition of mTORC2
por: Murray, Elizabeth R., et al.
Publicado: (2017)

Exosome Release Is Regulated by mTORC1
por: Zou, Wenchong, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_te571lu7jjtpaubv2p7tfvkcq3