Neuraminidase 1 activates insulin receptor and reverses insulin resistance in obese mice

OBJECTIVES: Neuraminidase 1 (NEU1) cleaves terminal sialic acids of glycoconjugates during lysosomal catabolism. It also modulates the structure and activity of cellular surface receptors affecting diverse pathways. Previously we demonstrated that NEU1 activates the insulin receptor (IR) and that NE...

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Detalles Bibliográficos
Autores principales: Fougerat, Anne, Pan, Xuefang, Smutova, Victoria, Heveker, Nikolaus, Cairo, Christopher W., Issad, Tarik, Larrivée, Bruno, Medin, Jeffrey A., Pshezhetsky, Alexey V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2018
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6001920/
https://www.ncbi.nlm.nih.gov/pubmed/29735266
http://dx.doi.org/10.1016/j.molmet.2018.03.017

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6001920/
https://www.ncbi.nlm.nih.gov/pubmed/29735266
http://dx.doi.org/10.1016/j.molmet.2018.03.017

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