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Infectious diarrhea in autologous stem cell transplantation: high prevalence of coccidia in a South American center

BACKGROUND: Diarrhea is frequently seen in autologous stem cell transplantation. Although toxicity related to conditioning is the most common cause, infectious pathogens can play a distinctive role particularly in certain regions and environments. METHODS: The role of enteropathogens was investigate...

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Autores principales: Castro, Marcelo Dias de, Chebli, Julio Maria, Costa, Luciano José, Alves, Katia Regina Lopes, Atalla, Angelo, Neto, Abrahao E. Hallack
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Sociedade Brasileira de Hematologia e Hemoterapia 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6001927/
https://www.ncbi.nlm.nih.gov/pubmed/30057986
http://dx.doi.org/10.1016/j.htct.2017.10.002
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author Castro, Marcelo Dias de
Chebli, Julio Maria
Costa, Luciano José
Alves, Katia Regina Lopes
Atalla, Angelo
Neto, Abrahao E. Hallack
author_facet Castro, Marcelo Dias de
Chebli, Julio Maria
Costa, Luciano José
Alves, Katia Regina Lopes
Atalla, Angelo
Neto, Abrahao E. Hallack
author_sort Castro, Marcelo Dias de
collection PubMed
description BACKGROUND: Diarrhea is frequently seen in autologous stem cell transplantation. Although toxicity related to conditioning is the most common cause, infectious pathogens can play a distinctive role particularly in certain regions and environments. METHODS: The role of enteropathogens was investigated in 47 patients submitted to autologous stem cell transplantation at a Brazilian center between May 2011 and May 2013. All patients who presented with diarrhea consented to stool sample analysis to identify the etiological agents including coccidia, Strongyloides sp., Clostridium difficile and other pathogenic bacteria. RESULTS: Thirty-nine patients (83%) had diarrhea, among whom seven (17.5%) presented with coccidia, three (7.5%) with Candida sp., one (2.5%) with C. difficile, and one (2.5%) with Giardia lamblia. There was a tendency toward a higher incidence of diarrhea in older patients (p-value = 0.09) and those who received conditioning with lomustine, etoposide, cytarabine, and melphalan (p-value = 0.083). Furthermore, the number of days of neutropenia was higher in patients with diarrhea (p-value = 0.06). CONCLUSIONS: The high frequency of diarrhea caused by coccidia shows the importance of investigating and correctly identifying etiological agents and highlights the possible varieties of intestinal infections in patients who undergo autologous stem cell transplantation.
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spelling pubmed-60019272018-06-15 Infectious diarrhea in autologous stem cell transplantation: high prevalence of coccidia in a South American center Castro, Marcelo Dias de Chebli, Julio Maria Costa, Luciano José Alves, Katia Regina Lopes Atalla, Angelo Neto, Abrahao E. Hallack Hematol Transfus Cell Ther Original Article BACKGROUND: Diarrhea is frequently seen in autologous stem cell transplantation. Although toxicity related to conditioning is the most common cause, infectious pathogens can play a distinctive role particularly in certain regions and environments. METHODS: The role of enteropathogens was investigated in 47 patients submitted to autologous stem cell transplantation at a Brazilian center between May 2011 and May 2013. All patients who presented with diarrhea consented to stool sample analysis to identify the etiological agents including coccidia, Strongyloides sp., Clostridium difficile and other pathogenic bacteria. RESULTS: Thirty-nine patients (83%) had diarrhea, among whom seven (17.5%) presented with coccidia, three (7.5%) with Candida sp., one (2.5%) with C. difficile, and one (2.5%) with Giardia lamblia. There was a tendency toward a higher incidence of diarrhea in older patients (p-value = 0.09) and those who received conditioning with lomustine, etoposide, cytarabine, and melphalan (p-value = 0.083). Furthermore, the number of days of neutropenia was higher in patients with diarrhea (p-value = 0.06). CONCLUSIONS: The high frequency of diarrhea caused by coccidia shows the importance of investigating and correctly identifying etiological agents and highlights the possible varieties of intestinal infections in patients who undergo autologous stem cell transplantation. Sociedade Brasileira de Hematologia e Hemoterapia 2018 2018-02-17 /pmc/articles/PMC6001927/ /pubmed/30057986 http://dx.doi.org/10.1016/j.htct.2017.10.002 Text en © 2018 Associação Brasileira de Hematologia, Hemoterapia e Terapia Celular. Published by Elsevier Editora Ltda. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Original Article
Castro, Marcelo Dias de
Chebli, Julio Maria
Costa, Luciano José
Alves, Katia Regina Lopes
Atalla, Angelo
Neto, Abrahao E. Hallack
Infectious diarrhea in autologous stem cell transplantation: high prevalence of coccidia in a South American center
title Infectious diarrhea in autologous stem cell transplantation: high prevalence of coccidia in a South American center
title_full Infectious diarrhea in autologous stem cell transplantation: high prevalence of coccidia in a South American center
title_fullStr Infectious diarrhea in autologous stem cell transplantation: high prevalence of coccidia in a South American center
title_full_unstemmed Infectious diarrhea in autologous stem cell transplantation: high prevalence of coccidia in a South American center
title_short Infectious diarrhea in autologous stem cell transplantation: high prevalence of coccidia in a South American center
title_sort infectious diarrhea in autologous stem cell transplantation: high prevalence of coccidia in a south american center
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6001927/
https://www.ncbi.nlm.nih.gov/pubmed/30057986
http://dx.doi.org/10.1016/j.htct.2017.10.002
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