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Does Incipient Dementia Explain Normal Cognitive Decline Determinants? Lothian Birth Cohort 1921

The presence of an apolipoprotein E (APOE) ε4 allele, lower physical fitness, smoking, and lower serum vitamin B-12 have been reported as contributing to poorer cognitive function in LBC1921 at age 79, after adjusting for childhood intelligence. Because incident dementia was not previously ascertain...

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Autores principales: Sibbett, Ruth A., Russ, Tom C., Pattie, Alison, Starr, John M., Deary, Ian J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Psychological Association 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6001941/
https://www.ncbi.nlm.nih.gov/pubmed/29745686
http://dx.doi.org/10.1037/pag0000241
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author Sibbett, Ruth A.
Russ, Tom C.
Pattie, Alison
Starr, John M.
Deary, Ian J.
author_facet Sibbett, Ruth A.
Russ, Tom C.
Pattie, Alison
Starr, John M.
Deary, Ian J.
author_sort Sibbett, Ruth A.
collection PubMed
description The presence of an apolipoprotein E (APOE) ε4 allele, lower physical fitness, smoking, and lower serum vitamin B-12 have been reported as contributing to poorer cognitive function in LBC1921 at age 79, after adjusting for childhood intelligence. Because incident dementia was not previously ascertained within LBC1921, it is possible that preclinical or unrecognized cases at age 79 influenced findings. Dementia cases arising over approximately 16 years of follow-up were determined by a consensus using evidence from electronic medical records, death certificates, and clinical reviews. The analyses from the original reports were repeated after the exclusion of those who had developed dementia. In a subsequent set of analyses, the authors considered the potential impact of terminal decline, excluding those participants who died within 4 years of baseline testing. Positive APOE ε4 status was found to be associated with poorer Logical Memory (Wechsler, 1987) at age 79 (F(1, 355) = 8.16, p = .005, η(p)(2) = 0.022; n = 359) and lower Moray House Test (Scottish Council for Research in Education, 1933) score at age 79 (F(1, 357) = 4.27, p = .04, η(p)(2) = 0.012; n = 363). Lower age 79 IQ was associated with smoking (F(2, 360) = 3.67, p = .026, η(p)(2) = 0.020; n = 367), lower vitamin B-12 (Sβ = 0.11, p = .014; n = 367), and poorer physical fitness (Sβ = 0.21, p < .001; n = 359). Only the relationship with physical fitness remained significant after excluding those who died within 4 years of baseline (Sβ = 0.203, p < .001; n = 310). Unrecognized dementia had little or no effect on determinants of lifetime cognitive ageing in LBC1921. Terminal decline may have accounted for the associations with age 11 to age 79 cognitive change.
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spelling pubmed-60019412018-06-19 Does Incipient Dementia Explain Normal Cognitive Decline Determinants? Lothian Birth Cohort 1921 Sibbett, Ruth A. Russ, Tom C. Pattie, Alison Starr, John M. Deary, Ian J. Psychol Aging Articles The presence of an apolipoprotein E (APOE) ε4 allele, lower physical fitness, smoking, and lower serum vitamin B-12 have been reported as contributing to poorer cognitive function in LBC1921 at age 79, after adjusting for childhood intelligence. Because incident dementia was not previously ascertained within LBC1921, it is possible that preclinical or unrecognized cases at age 79 influenced findings. Dementia cases arising over approximately 16 years of follow-up were determined by a consensus using evidence from electronic medical records, death certificates, and clinical reviews. The analyses from the original reports were repeated after the exclusion of those who had developed dementia. In a subsequent set of analyses, the authors considered the potential impact of terminal decline, excluding those participants who died within 4 years of baseline testing. Positive APOE ε4 status was found to be associated with poorer Logical Memory (Wechsler, 1987) at age 79 (F(1, 355) = 8.16, p = .005, η(p)(2) = 0.022; n = 359) and lower Moray House Test (Scottish Council for Research in Education, 1933) score at age 79 (F(1, 357) = 4.27, p = .04, η(p)(2) = 0.012; n = 363). Lower age 79 IQ was associated with smoking (F(2, 360) = 3.67, p = .026, η(p)(2) = 0.020; n = 367), lower vitamin B-12 (Sβ = 0.11, p = .014; n = 367), and poorer physical fitness (Sβ = 0.21, p < .001; n = 359). Only the relationship with physical fitness remained significant after excluding those who died within 4 years of baseline (Sβ = 0.203, p < .001; n = 310). Unrecognized dementia had little or no effect on determinants of lifetime cognitive ageing in LBC1921. Terminal decline may have accounted for the associations with age 11 to age 79 cognitive change. American Psychological Association 2018-05-10 2018-06 /pmc/articles/PMC6001941/ /pubmed/29745686 http://dx.doi.org/10.1037/pag0000241 Text en © 2018 The Author(s) http://creativecommons.org/licenses/by/3.0/ This article has been published under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Copyright for this article is retained by the author(s). Author(s) grant(s) the American Psychological Association the exclusive right to publish the article and identify itself as the original publisher.
spellingShingle Articles
Sibbett, Ruth A.
Russ, Tom C.
Pattie, Alison
Starr, John M.
Deary, Ian J.
Does Incipient Dementia Explain Normal Cognitive Decline Determinants? Lothian Birth Cohort 1921
title Does Incipient Dementia Explain Normal Cognitive Decline Determinants? Lothian Birth Cohort 1921
title_full Does Incipient Dementia Explain Normal Cognitive Decline Determinants? Lothian Birth Cohort 1921
title_fullStr Does Incipient Dementia Explain Normal Cognitive Decline Determinants? Lothian Birth Cohort 1921
title_full_unstemmed Does Incipient Dementia Explain Normal Cognitive Decline Determinants? Lothian Birth Cohort 1921
title_short Does Incipient Dementia Explain Normal Cognitive Decline Determinants? Lothian Birth Cohort 1921
title_sort does incipient dementia explain normal cognitive decline determinants? lothian birth cohort 1921
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6001941/
https://www.ncbi.nlm.nih.gov/pubmed/29745686
http://dx.doi.org/10.1037/pag0000241
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