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Rapid high resolution T1 mapping as a marker of brain development: Normative ranges in key regions of interest

OBJECTIVES: We studied in a clinical setting the age dependent T1 relaxation time as a marker of normal late brain maturation and compared it to conventional techniques, namely the apparent diffusion coefficient (ADC). MATERIALS AND METHODS: Forty-two healthy subjects ranging from ages 1 year to 20...

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Autores principales: Eminian, Sylvain, Hajdu, Steven David, Meuli, Reto Antoine, Maeder, Philippe, Hagmann, Patric
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6002025/
https://www.ncbi.nlm.nih.gov/pubmed/29902203
http://dx.doi.org/10.1371/journal.pone.0198250
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author Eminian, Sylvain
Hajdu, Steven David
Meuli, Reto Antoine
Maeder, Philippe
Hagmann, Patric
author_facet Eminian, Sylvain
Hajdu, Steven David
Meuli, Reto Antoine
Maeder, Philippe
Hagmann, Patric
author_sort Eminian, Sylvain
collection PubMed
description OBJECTIVES: We studied in a clinical setting the age dependent T1 relaxation time as a marker of normal late brain maturation and compared it to conventional techniques, namely the apparent diffusion coefficient (ADC). MATERIALS AND METHODS: Forty-two healthy subjects ranging from ages 1 year to 20 years were included in our study. T1 brain maps in which the intensity of each pixel corresponded to T1 relaxation times were generated based on MR imaging data acquired using a MP2RAGE sequence. During the same session, diffusion tensor imaging data was collected. T1 relaxation times and ADC in white matter and grey matter were measured in seven clinically relevant regions of interest and were correlated to subjects’ age. RESULTS: In the basal ganglia, there was a small, yet significant, decrease in T1 relaxation time (-0.45 ≤R≤-0.59, p<10(−2)) and ADC (-0.60≤R≤-0.65, p<10(−4)) as a function of age. In the frontal and parietal white matter, there was a significant decrease in T1 relaxation time (-0.62≤R≤-0.68, p<10(−4)) and ADC (-0.81≤R≤-0.85, p<10(−4)) as a function of age. T1 relaxation time changes in the corpus callosum and internal capsule were less relevant for this age range. There was no significant difference between the correlation of T1 relaxation time and ADC with respect to age (p-value = 0.39). The correlation between T1 relaxation and ADC is strong in the white matter but only moderate in basal ganglia over this age period. CONCLUSIONS: T1 relaxation time is a marker of brain maturation or myelination during late brain development. Between the age of 1 and 20 years, T1 relaxation time decreases as a function of age in the white matter and basal ganglia. The greatest changes occur in frontal and parietal white matter. These regions are known to mature in the final stage of development and are mainly composed of association circuits. Age-correlation is not significantly different between T1 relaxation time and ADC. Therefore, T1 relaxation time does not appear to be a superior marker of brain maturation than ADC but may be considered as complementary owing the intrinsic differences in bio-physical sensitivity. This work may serve as normative ranges in clinical imaging routines.
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spelling pubmed-60020252018-06-25 Rapid high resolution T1 mapping as a marker of brain development: Normative ranges in key regions of interest Eminian, Sylvain Hajdu, Steven David Meuli, Reto Antoine Maeder, Philippe Hagmann, Patric PLoS One Research Article OBJECTIVES: We studied in a clinical setting the age dependent T1 relaxation time as a marker of normal late brain maturation and compared it to conventional techniques, namely the apparent diffusion coefficient (ADC). MATERIALS AND METHODS: Forty-two healthy subjects ranging from ages 1 year to 20 years were included in our study. T1 brain maps in which the intensity of each pixel corresponded to T1 relaxation times were generated based on MR imaging data acquired using a MP2RAGE sequence. During the same session, diffusion tensor imaging data was collected. T1 relaxation times and ADC in white matter and grey matter were measured in seven clinically relevant regions of interest and were correlated to subjects’ age. RESULTS: In the basal ganglia, there was a small, yet significant, decrease in T1 relaxation time (-0.45 ≤R≤-0.59, p<10(−2)) and ADC (-0.60≤R≤-0.65, p<10(−4)) as a function of age. In the frontal and parietal white matter, there was a significant decrease in T1 relaxation time (-0.62≤R≤-0.68, p<10(−4)) and ADC (-0.81≤R≤-0.85, p<10(−4)) as a function of age. T1 relaxation time changes in the corpus callosum and internal capsule were less relevant for this age range. There was no significant difference between the correlation of T1 relaxation time and ADC with respect to age (p-value = 0.39). The correlation between T1 relaxation and ADC is strong in the white matter but only moderate in basal ganglia over this age period. CONCLUSIONS: T1 relaxation time is a marker of brain maturation or myelination during late brain development. Between the age of 1 and 20 years, T1 relaxation time decreases as a function of age in the white matter and basal ganglia. The greatest changes occur in frontal and parietal white matter. These regions are known to mature in the final stage of development and are mainly composed of association circuits. Age-correlation is not significantly different between T1 relaxation time and ADC. Therefore, T1 relaxation time does not appear to be a superior marker of brain maturation than ADC but may be considered as complementary owing the intrinsic differences in bio-physical sensitivity. This work may serve as normative ranges in clinical imaging routines. Public Library of Science 2018-06-14 /pmc/articles/PMC6002025/ /pubmed/29902203 http://dx.doi.org/10.1371/journal.pone.0198250 Text en © 2018 Eminian et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Eminian, Sylvain
Hajdu, Steven David
Meuli, Reto Antoine
Maeder, Philippe
Hagmann, Patric
Rapid high resolution T1 mapping as a marker of brain development: Normative ranges in key regions of interest
title Rapid high resolution T1 mapping as a marker of brain development: Normative ranges in key regions of interest
title_full Rapid high resolution T1 mapping as a marker of brain development: Normative ranges in key regions of interest
title_fullStr Rapid high resolution T1 mapping as a marker of brain development: Normative ranges in key regions of interest
title_full_unstemmed Rapid high resolution T1 mapping as a marker of brain development: Normative ranges in key regions of interest
title_short Rapid high resolution T1 mapping as a marker of brain development: Normative ranges in key regions of interest
title_sort rapid high resolution t1 mapping as a marker of brain development: normative ranges in key regions of interest
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6002025/
https://www.ncbi.nlm.nih.gov/pubmed/29902203
http://dx.doi.org/10.1371/journal.pone.0198250
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