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PIK3CA copy number aberration and activation of the PI3K-AKT-mTOR pathway in varied disease states of penile cancer

BACKGROUND: Therapeutic targeting of the PI3K-AKT-mTOR pathway may benefit patients with advanced penile squamous cell carcinoma (PSCC). OBJECTIVES: To determine the prevalence of PIK3CA copy number gain and correlate this with the activity status of PI3K-AKT-mTOR pathway in pre-malignant penile int...

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Detalles Bibliográficos
Autores principales:	Adimonye, Anthony, Stankiewicz, Elzbieta, La-Touche, Susannah, Kudahetti, Sakunthala, Trevisan, Giorgia, Tinwell, Brendan, Corbishley, Cathy, Lu, Yong-Jie, Watkin, Nick, Berney, Daniel
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2018
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6002057/ https://www.ncbi.nlm.nih.gov/pubmed/29902261 http://dx.doi.org/10.1371/journal.pone.0198905

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