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Validated UPLC-MS/MS method for the quantification of dasatinib in plasma: Application to pharmacokinetic interaction studies with nutraceuticals in Wistar rats

Dasatinib (DAS) is a tyrosine kinase inhibitor (TKI) used in the treatment of chronic myeloid leukemia and in the management of ulcerative colitis (UC). Since some nutraceuticals (e.g. curcumin, olive oil, and cocoa extract) could alter the function of ABC transporters and /or CYP450 enzymes, DAS bi...

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Detalles Bibliográficos
Autores principales:	Maher, Hadir M., Alzoman, Nourah Z., Shehata, Shereen M., Abanmy, Norah O.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2018
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6002064/ https://www.ncbi.nlm.nih.gov/pubmed/29902246 http://dx.doi.org/10.1371/journal.pone.0199208

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