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Lat(Y136F) knock-in mouse model for human IgG4-related disease

BACKGROUND: The adaptor protein Linker for activation of T cell (LAT) is a key signaling hub used by the T cell antigen receptor. Mutant mice expressing loss-of-function mutations affecting LAT and including a mutation in which tyrosine 136 is replaced by a phenylalanine (Lat(Y136F)) develop lymphop...

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Detalles Bibliográficos
Autores principales:	Yamada, Kazunori, Zuka, Masahiko, Ito, Kiyoaki, Mizuguchi, Keishi, Kakuchi, Yasushi, Onoe, Tamehito, Suzuki, Yasunori, Yamagishi, Masakazu, Izui, Shozo, Malissen, Marie, Malissen, Bernard, Kawano, Mitsuhiro
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2018
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6002065/ https://www.ncbi.nlm.nih.gov/pubmed/29902238 http://dx.doi.org/10.1371/journal.pone.0198417

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