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Effect of Topical Steroids on Skin Prick Test: A Randomized Controlled Trial

INTRODUCTION: Topically applied corticosteroids on the skin can significantly inhibit the wheal response to allergens in skin prick test (SPT). The duration of this effect is unknown. The aim of this study is to investigate the duration of the inhibitory effect of topical corticosteroids on SPT. MET...

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Autores principales: Ebbesen, Anne R., Riis, Lene A., Gradman, Josefine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Healthcare 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6002313/
https://www.ncbi.nlm.nih.gov/pubmed/29728933
http://dx.doi.org/10.1007/s13555-018-0238-1
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author Ebbesen, Anne R.
Riis, Lene A.
Gradman, Josefine
author_facet Ebbesen, Anne R.
Riis, Lene A.
Gradman, Josefine
author_sort Ebbesen, Anne R.
collection PubMed
description INTRODUCTION: Topically applied corticosteroids on the skin can significantly inhibit the wheal response to allergens in skin prick test (SPT). The duration of this effect is unknown. The aim of this study is to investigate the duration of the inhibitory effect of topical corticosteroids on SPT. METHODS: Twenty-two healthy subjects were included in a single-blinded randomized study. All subjects were skin prick tested using a standard inhalant allergen panel. The subjects were randomized to treat either the left or right forearm with Betnovat(®) cream (group III steroid) once a day for 10 days. Subsequently, the subjects were skin prick tested the following 5 days and at day 8 on both forearms. RESULTS: At baseline, the 22 individuals had positive SPT for a total of 72 allergens. Compared with the untreated arm, the mean size of the wheals was significantly reduced on day 1 (12 h after end of treatment) by 0.56 mm (95 % confidence interval (CI) [0.06; 1.06], p = 0.03) for allergens and 0.70 mm [0.32; 1.09] (p = 0.001) for histamine. On day 2 (36 h after end of treatment), the mean difference between treated and untreated arm was 0.47 mm [−0.08; 0.85] (p = 0.02) for allergen-induced wheals and 0.22 mm [−0.21; 0.64] (p = 0.31) for histamine-induced wheal. On day 3, 4, 5, and 8, there was no significant difference. CONCLUSIONS: Treatment with topical steroid significantly inhibited the response to SPT for 36 h but for less than 3 days. In addition, we demonstrated that topical applied corticosteroids inhibit the mean wheal size of the positive histamine control for a shorter time than for the allergens. Consequently, positive response to histamine control is not a valid marker for reliable skin prick test in steroid-treated patients. PLAIN LANGUAGE SUMMARY: Plain language summary available for this article.
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spelling pubmed-60023132018-06-29 Effect of Topical Steroids on Skin Prick Test: A Randomized Controlled Trial Ebbesen, Anne R. Riis, Lene A. Gradman, Josefine Dermatol Ther (Heidelb) Original Research INTRODUCTION: Topically applied corticosteroids on the skin can significantly inhibit the wheal response to allergens in skin prick test (SPT). The duration of this effect is unknown. The aim of this study is to investigate the duration of the inhibitory effect of topical corticosteroids on SPT. METHODS: Twenty-two healthy subjects were included in a single-blinded randomized study. All subjects were skin prick tested using a standard inhalant allergen panel. The subjects were randomized to treat either the left or right forearm with Betnovat(®) cream (group III steroid) once a day for 10 days. Subsequently, the subjects were skin prick tested the following 5 days and at day 8 on both forearms. RESULTS: At baseline, the 22 individuals had positive SPT for a total of 72 allergens. Compared with the untreated arm, the mean size of the wheals was significantly reduced on day 1 (12 h after end of treatment) by 0.56 mm (95 % confidence interval (CI) [0.06; 1.06], p = 0.03) for allergens and 0.70 mm [0.32; 1.09] (p = 0.001) for histamine. On day 2 (36 h after end of treatment), the mean difference between treated and untreated arm was 0.47 mm [−0.08; 0.85] (p = 0.02) for allergen-induced wheals and 0.22 mm [−0.21; 0.64] (p = 0.31) for histamine-induced wheal. On day 3, 4, 5, and 8, there was no significant difference. CONCLUSIONS: Treatment with topical steroid significantly inhibited the response to SPT for 36 h but for less than 3 days. In addition, we demonstrated that topical applied corticosteroids inhibit the mean wheal size of the positive histamine control for a shorter time than for the allergens. Consequently, positive response to histamine control is not a valid marker for reliable skin prick test in steroid-treated patients. PLAIN LANGUAGE SUMMARY: Plain language summary available for this article. Springer Healthcare 2018-05-04 /pmc/articles/PMC6002313/ /pubmed/29728933 http://dx.doi.org/10.1007/s13555-018-0238-1 Text en © The Author(s) 2018 https://creativecommons.org/licenses/by-nc/4.0/This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) ), which permits any noncommercial use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Original Research
Ebbesen, Anne R.
Riis, Lene A.
Gradman, Josefine
Effect of Topical Steroids on Skin Prick Test: A Randomized Controlled Trial
title Effect of Topical Steroids on Skin Prick Test: A Randomized Controlled Trial
title_full Effect of Topical Steroids on Skin Prick Test: A Randomized Controlled Trial
title_fullStr Effect of Topical Steroids on Skin Prick Test: A Randomized Controlled Trial
title_full_unstemmed Effect of Topical Steroids on Skin Prick Test: A Randomized Controlled Trial
title_short Effect of Topical Steroids on Skin Prick Test: A Randomized Controlled Trial
title_sort effect of topical steroids on skin prick test: a randomized controlled trial
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6002313/
https://www.ncbi.nlm.nih.gov/pubmed/29728933
http://dx.doi.org/10.1007/s13555-018-0238-1
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