β-catenin knockdown promotes NHERF1-mediated survival of colorectal cancer cells: implications for a double-targeted therapy

Nuclear activated β-catenin plays a causative role in colorectal cancers (CRC) but remains an elusive therapeutic target. Using human CRC cells harboring different Wnt/β-catenin pathway mutations in APC/KRAS or β-catenin/KRAS genes, and both genetic and pharmacological knockdown approaches, we show...

Descripción completa

Detalles Bibliográficos
Autores principales: Saponaro, Concetta, Sergio, Sara, Coluccia, Antonio, De Luca, Maria, La Regina, Giuseppe, Mologni, Luca, Famiglini, Valeria, Naccarato, Valentina, Bonetti, Daniela, Gautier, Candice, Gianni, Stefano, Vergara, Daniele, Salzet, Michel, Fournier, Isabelle, Bucci, Cecilia, Silvestri, Romano, Passerini, Carlo Gambacorti, Maffia, Michele, Coluccia, Addolorata Maria Luce
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6002344/
https://www.ncbi.nlm.nih.gov/pubmed/29551770
http://dx.doi.org/10.1038/s41388-018-0170-y

Ejemplares similares

Ejemplares similares