Cargando…
Metabolic conversion of CI-1040 turns a cellular MEK-inhibitor into an antibacterial compound
Influenza virus (IV) infections cause severe respiratory illnesses that can be complicated by bacterial super-infections. Previously, we identified the cellular Raf-MEK-ERK cascade as a promising antiviral target. Inhibitors of MEK, such as CI-1040, showed potent antiviral activity. However, it rema...
Autores principales: | Bruchhagen, Christin, Jarick, Marcel, Mewis, Carolin, Hertlein, Tobias, Niemann, Silke, Ohlsen, Knut, Peters, Georg, Planz, Oliver, Ludwig, Stephan, Ehrhardt, Christina |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2018
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6002397/ https://www.ncbi.nlm.nih.gov/pubmed/29904167 http://dx.doi.org/10.1038/s41598-018-27445-7 |
Ejemplares similares
-
Mitogen-activated protein kinases (MAPKs) regulate IL-6 over-production during concomitant influenza virus and Staphylococcus aureus infection
por: Klemm, Carolin, et al.
Publicado: (2017) -
Combination of Rapamycin, CI-1040, and 17-AAG Inhibits Metastatic Capacity of Prostate Cancer via Slug Inhibition
por: Ding, Guanxiong, et al.
Publicado: (2013) -
Novel Effective Small-Molecule Antibacterials against Enterococcus Strains
por: Ashraf, Kerolos, et al.
Publicado: (2017) -
Novel Small-Molecule Hybrid-Antibacterial Agents against S. aureus and MRSA Strains
por: Gehrmann, Robin, et al.
Publicado: (2021) -
Towards clinical application of non-invasive imaging to detect bacterial infections
por: Ohlsen, Knut, et al.
Publicado: (2018)