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Danger signals in trauma
This review summarizes a short list of currently discussed trauma-induced danger-associated molecular patterns (DAMP). Due to the bivalent character and often pleiotropic effects of a DAMP, it is difficult to describe its “friend or foe” role in post-traumatic inflammation and regeneration, both sys...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer Berlin Heidelberg
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6002466/ https://www.ncbi.nlm.nih.gov/pubmed/29728738 http://dx.doi.org/10.1007/s00068-018-0962-3 |
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author | Relja, Borna Mörs, Katharina Marzi, Ingo |
author_facet | Relja, Borna Mörs, Katharina Marzi, Ingo |
author_sort | Relja, Borna |
collection | PubMed |
description | This review summarizes a short list of currently discussed trauma-induced danger-associated molecular patterns (DAMP). Due to the bivalent character and often pleiotropic effects of a DAMP, it is difficult to describe its “friend or foe” role in post-traumatic inflammation and regeneration, both systemically as well locally in tissues. DAMP can be used as biomarkers to indicate or monitor disease or injury severity, but also may serve as clinically applicable parameters for better indication and timing of surgery. Due to the inflammatory processes at the local tissue level or the systemic level, the precise role of DAMP is not always clear to define. While in vitro and experimental studies allow for the detection of these biomarkers at the different levels of an organism—cellular, tissue, circulation—this is not always easily transferable to the human setting. Increased knowledge exploring the dual role of DAMP after trauma, and concentrating on their nuclear functions, transcriptional targets, release mechanisms, cellular sources, multiple functions, their interactions and potential therapeutic targeting is warranted. |
format | Online Article Text |
id | pubmed-6002466 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Springer Berlin Heidelberg |
record_format | MEDLINE/PubMed |
spelling | pubmed-60024662018-06-29 Danger signals in trauma Relja, Borna Mörs, Katharina Marzi, Ingo Eur J Trauma Emerg Surg Review Article This review summarizes a short list of currently discussed trauma-induced danger-associated molecular patterns (DAMP). Due to the bivalent character and often pleiotropic effects of a DAMP, it is difficult to describe its “friend or foe” role in post-traumatic inflammation and regeneration, both systemically as well locally in tissues. DAMP can be used as biomarkers to indicate or monitor disease or injury severity, but also may serve as clinically applicable parameters for better indication and timing of surgery. Due to the inflammatory processes at the local tissue level or the systemic level, the precise role of DAMP is not always clear to define. While in vitro and experimental studies allow for the detection of these biomarkers at the different levels of an organism—cellular, tissue, circulation—this is not always easily transferable to the human setting. Increased knowledge exploring the dual role of DAMP after trauma, and concentrating on their nuclear functions, transcriptional targets, release mechanisms, cellular sources, multiple functions, their interactions and potential therapeutic targeting is warranted. Springer Berlin Heidelberg 2018-05-04 2018 /pmc/articles/PMC6002466/ /pubmed/29728738 http://dx.doi.org/10.1007/s00068-018-0962-3 Text en © The Author(s) 2018 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. |
spellingShingle | Review Article Relja, Borna Mörs, Katharina Marzi, Ingo Danger signals in trauma |
title | Danger signals in trauma |
title_full | Danger signals in trauma |
title_fullStr | Danger signals in trauma |
title_full_unstemmed | Danger signals in trauma |
title_short | Danger signals in trauma |
title_sort | danger signals in trauma |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6002466/ https://www.ncbi.nlm.nih.gov/pubmed/29728738 http://dx.doi.org/10.1007/s00068-018-0962-3 |
work_keys_str_mv | AT reljaborna dangersignalsintrauma AT morskatharina dangersignalsintrauma AT marziingo dangersignalsintrauma |