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Evidence of No Association Between Human Papillomavirus and Breast Cancer

BACKGROUND: Globally, breast cancer is the most frequent cancer among women. Studies reported an increased risk of breast cancer among women with prior cervical dysplasia. This study aimed to describe the prevalence of human papillomavirus (HPV) in breast cancer and explore if women with prior cervi...

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Autores principales: Bønløkke, Sara, Blaakær, Jan, Steiniche, Torben, Høgdall, Estrid, Jensen, Steffen Grann, Hammer, Anne, Balslev, Eva, Strube, Mikael Lenz, Knakkergaard, Helle, Lenz, Suzan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6002490/
https://www.ncbi.nlm.nih.gov/pubmed/29938198
http://dx.doi.org/10.3389/fonc.2018.00209
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author Bønløkke, Sara
Blaakær, Jan
Steiniche, Torben
Høgdall, Estrid
Jensen, Steffen Grann
Hammer, Anne
Balslev, Eva
Strube, Mikael Lenz
Knakkergaard, Helle
Lenz, Suzan
author_facet Bønløkke, Sara
Blaakær, Jan
Steiniche, Torben
Høgdall, Estrid
Jensen, Steffen Grann
Hammer, Anne
Balslev, Eva
Strube, Mikael Lenz
Knakkergaard, Helle
Lenz, Suzan
author_sort Bønløkke, Sara
collection PubMed
description BACKGROUND: Globally, breast cancer is the most frequent cancer among women. Studies reported an increased risk of breast cancer among women with prior cervical dysplasia. This study aimed to describe the prevalence of human papillomavirus (HPV) in breast cancer and explore if women with prior cervical neoplasia carry an increased risk of HPV-positive breast cancer compared to women without. METHODS: This case–control study identified 193 Danish women diagnosed with breast cancer (1998–2012) at Aarhus University Hospital or Copenhagen University Hospital Herlev. Cases were 93 women with cervical intraepithelial neoplasia grade 3 or worse (CIN3+) prior to breast cancer. Controls were 100 women without prior cervical dysplasia. HPV testing and genotyping were done using SPF(10) PCR-DEIA-LiPA(25) and an in-house semi-Q-PCR assay. RESULTS: Overall HPV prevalence in breast cancer for the assays was 1.55% (95% CI 0.32–4.48) and 0.52% (95% CI 0.01–2.85). There was no difference in HPV prevalence between cases and controls (2.15 vs. 1.00%, p = 0.61 and 1.08 vs. 0.00%, p = 0.48). HPV prevalence in CIN3+ was 94.62% (95% CI 0.88–0.98). Concordance between the assays was 98.60%. CONCLUSION: HPV prevalence in breast cancer is very low suggesting no etiological correlation between HPV and breast cancer.
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spelling pubmed-60024902018-06-22 Evidence of No Association Between Human Papillomavirus and Breast Cancer Bønløkke, Sara Blaakær, Jan Steiniche, Torben Høgdall, Estrid Jensen, Steffen Grann Hammer, Anne Balslev, Eva Strube, Mikael Lenz Knakkergaard, Helle Lenz, Suzan Front Oncol Oncology BACKGROUND: Globally, breast cancer is the most frequent cancer among women. Studies reported an increased risk of breast cancer among women with prior cervical dysplasia. This study aimed to describe the prevalence of human papillomavirus (HPV) in breast cancer and explore if women with prior cervical neoplasia carry an increased risk of HPV-positive breast cancer compared to women without. METHODS: This case–control study identified 193 Danish women diagnosed with breast cancer (1998–2012) at Aarhus University Hospital or Copenhagen University Hospital Herlev. Cases were 93 women with cervical intraepithelial neoplasia grade 3 or worse (CIN3+) prior to breast cancer. Controls were 100 women without prior cervical dysplasia. HPV testing and genotyping were done using SPF(10) PCR-DEIA-LiPA(25) and an in-house semi-Q-PCR assay. RESULTS: Overall HPV prevalence in breast cancer for the assays was 1.55% (95% CI 0.32–4.48) and 0.52% (95% CI 0.01–2.85). There was no difference in HPV prevalence between cases and controls (2.15 vs. 1.00%, p = 0.61 and 1.08 vs. 0.00%, p = 0.48). HPV prevalence in CIN3+ was 94.62% (95% CI 0.88–0.98). Concordance between the assays was 98.60%. CONCLUSION: HPV prevalence in breast cancer is very low suggesting no etiological correlation between HPV and breast cancer. Frontiers Media S.A. 2018-06-08 /pmc/articles/PMC6002490/ /pubmed/29938198 http://dx.doi.org/10.3389/fonc.2018.00209 Text en Copyright © 2018 Bønløkke, Blaakær, Steiniche, Høgdall, Jensen, Hammer, Balslev, Strube, Knakkergaard and Lenz. https://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Bønløkke, Sara
Blaakær, Jan
Steiniche, Torben
Høgdall, Estrid
Jensen, Steffen Grann
Hammer, Anne
Balslev, Eva
Strube, Mikael Lenz
Knakkergaard, Helle
Lenz, Suzan
Evidence of No Association Between Human Papillomavirus and Breast Cancer
title Evidence of No Association Between Human Papillomavirus and Breast Cancer
title_full Evidence of No Association Between Human Papillomavirus and Breast Cancer
title_fullStr Evidence of No Association Between Human Papillomavirus and Breast Cancer
title_full_unstemmed Evidence of No Association Between Human Papillomavirus and Breast Cancer
title_short Evidence of No Association Between Human Papillomavirus and Breast Cancer
title_sort evidence of no association between human papillomavirus and breast cancer
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6002490/
https://www.ncbi.nlm.nih.gov/pubmed/29938198
http://dx.doi.org/10.3389/fonc.2018.00209
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