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Multiple Sclerosis in the Asia Pacific Region: A Systematic Review of a Neglected Neurological Disease
Background: Multiple sclerosis is thought to be relatively uncommon in the Asia Pacific region with prevalence estimated between 0 and 20 per 100,000. There is reason to doubt these estimates due to the lack of data from many countries and the growing evidence of variability in prevalence across sma...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6002494/ https://www.ncbi.nlm.nih.gov/pubmed/29937752 http://dx.doi.org/10.3389/fneur.2018.00432 |
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author | Cheong, Wing L. Mohan, Devi Warren, Narelle Reidpath, Daniel D. |
author_facet | Cheong, Wing L. Mohan, Devi Warren, Narelle Reidpath, Daniel D. |
author_sort | Cheong, Wing L. |
collection | PubMed |
description | Background: Multiple sclerosis is thought to be relatively uncommon in the Asia Pacific region with prevalence estimated between 0 and 20 per 100,000. There is reason to doubt these estimates due to the lack of data from many countries and the growing evidence of variability in prevalence across small geographic areas. This study was conducted to systematically review the population prevalence, incidence, mortality and disability progression estimates of MS within the Asia Pacific region. Methods: The systematic review was conducted on articles from 1985 till 31st July 2017 within the PubMed/MEDLINE, EMBASE, SCOPUS, and The Cochrane Library databases. The review included articles that were population-based studies conducted on patients with MS in the Asia Pacific region that reported either incidence, prevalence, mortality, or disease progression. Hospital-based studies and non-research articles were excluded to ensure that only information representative of the population was included for analysis. Data appraisal and extraction was done by independent reviewers. This review was registered with PROSPERO (ID: CRD42017082760). Findings: Of the 2,757 articles found, 16 studies were included. Information on 6 (18.75%) of 32 Asia Pacific countries was found, with data representing 8% of the total population. Prevalence estimates were available for 6 countries while estimates for incidence (3 countries), mortality (4 countries), and disease progression (2 countries) were limited. Interpretation: The lack of epidemiological data available in the Asia Pacific region creates a blind spot in the surveillance of MS which obscures the true burden of MS, causing patients to struggle to receive the resources and funding that they need. |
format | Online Article Text |
id | pubmed-6002494 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-60024942018-06-22 Multiple Sclerosis in the Asia Pacific Region: A Systematic Review of a Neglected Neurological Disease Cheong, Wing L. Mohan, Devi Warren, Narelle Reidpath, Daniel D. Front Neurol Neurology Background: Multiple sclerosis is thought to be relatively uncommon in the Asia Pacific region with prevalence estimated between 0 and 20 per 100,000. There is reason to doubt these estimates due to the lack of data from many countries and the growing evidence of variability in prevalence across small geographic areas. This study was conducted to systematically review the population prevalence, incidence, mortality and disability progression estimates of MS within the Asia Pacific region. Methods: The systematic review was conducted on articles from 1985 till 31st July 2017 within the PubMed/MEDLINE, EMBASE, SCOPUS, and The Cochrane Library databases. The review included articles that were population-based studies conducted on patients with MS in the Asia Pacific region that reported either incidence, prevalence, mortality, or disease progression. Hospital-based studies and non-research articles were excluded to ensure that only information representative of the population was included for analysis. Data appraisal and extraction was done by independent reviewers. This review was registered with PROSPERO (ID: CRD42017082760). Findings: Of the 2,757 articles found, 16 studies were included. Information on 6 (18.75%) of 32 Asia Pacific countries was found, with data representing 8% of the total population. Prevalence estimates were available for 6 countries while estimates for incidence (3 countries), mortality (4 countries), and disease progression (2 countries) were limited. Interpretation: The lack of epidemiological data available in the Asia Pacific region creates a blind spot in the surveillance of MS which obscures the true burden of MS, causing patients to struggle to receive the resources and funding that they need. Frontiers Media S.A. 2018-06-08 /pmc/articles/PMC6002494/ /pubmed/29937752 http://dx.doi.org/10.3389/fneur.2018.00432 Text en Copyright © 2018 Cheong, Mohan, Warren and Reidpath. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Neurology Cheong, Wing L. Mohan, Devi Warren, Narelle Reidpath, Daniel D. Multiple Sclerosis in the Asia Pacific Region: A Systematic Review of a Neglected Neurological Disease |
title | Multiple Sclerosis in the Asia Pacific Region: A Systematic Review of a Neglected Neurological Disease |
title_full | Multiple Sclerosis in the Asia Pacific Region: A Systematic Review of a Neglected Neurological Disease |
title_fullStr | Multiple Sclerosis in the Asia Pacific Region: A Systematic Review of a Neglected Neurological Disease |
title_full_unstemmed | Multiple Sclerosis in the Asia Pacific Region: A Systematic Review of a Neglected Neurological Disease |
title_short | Multiple Sclerosis in the Asia Pacific Region: A Systematic Review of a Neglected Neurological Disease |
title_sort | multiple sclerosis in the asia pacific region: a systematic review of a neglected neurological disease |
topic | Neurology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6002494/ https://www.ncbi.nlm.nih.gov/pubmed/29937752 http://dx.doi.org/10.3389/fneur.2018.00432 |
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