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Red Blood Cell Homeostasis: Mechanisms and Effects of Microvesicle Generation in Health and Disease

Red blood cells (RBCs) generate microvesicles to remove damaged cell constituents such as oxidized hemoglobin and damaged membrane constituents, and thereby prolong their lifespan. Damage to hemoglobin, in combination with altered phosphorylation of membrane proteins such as band 3, lead to a weaken...

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Autores principales: Leal, Joames K. F., Adjobo-Hermans, Merel J. W., Bosman, Giel J. C. G. M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6002509/
https://www.ncbi.nlm.nih.gov/pubmed/29937736
http://dx.doi.org/10.3389/fphys.2018.00703
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author Leal, Joames K. F.
Adjobo-Hermans, Merel J. W.
Bosman, Giel J. C. G. M.
author_facet Leal, Joames K. F.
Adjobo-Hermans, Merel J. W.
Bosman, Giel J. C. G. M.
author_sort Leal, Joames K. F.
collection PubMed
description Red blood cells (RBCs) generate microvesicles to remove damaged cell constituents such as oxidized hemoglobin and damaged membrane constituents, and thereby prolong their lifespan. Damage to hemoglobin, in combination with altered phosphorylation of membrane proteins such as band 3, lead to a weakening of the binding between the lipid bilayer and the cytoskeleton, and thereby to membrane budding and microparticle shedding. Microvesicle generation is disturbed in patients with RBC-centered diseases, such as sickle cell disease, glucose 6-phosphate dehydrogenase deficiency, spherocytosis or malaria. A disturbance of the membrane-cytoskeleton interaction is likely to be the main underlying mechanism, as is supported by data obtained from RBCs stored in blood bank conditions. A detailed proteomic, lipidomic and immunogenic comparison of microvesicles derived from different sources is essential in the identification of the processes that trigger vesicle generation. The contribution of RBC-derived microvesicles to inflammation, thrombosis and autoimmune reactions emphasizes the need for a better understanding of the mechanisms and consequences of microvesicle generation.
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spelling pubmed-60025092018-06-22 Red Blood Cell Homeostasis: Mechanisms and Effects of Microvesicle Generation in Health and Disease Leal, Joames K. F. Adjobo-Hermans, Merel J. W. Bosman, Giel J. C. G. M. Front Physiol Physiology Red blood cells (RBCs) generate microvesicles to remove damaged cell constituents such as oxidized hemoglobin and damaged membrane constituents, and thereby prolong their lifespan. Damage to hemoglobin, in combination with altered phosphorylation of membrane proteins such as band 3, lead to a weakening of the binding between the lipid bilayer and the cytoskeleton, and thereby to membrane budding and microparticle shedding. Microvesicle generation is disturbed in patients with RBC-centered diseases, such as sickle cell disease, glucose 6-phosphate dehydrogenase deficiency, spherocytosis or malaria. A disturbance of the membrane-cytoskeleton interaction is likely to be the main underlying mechanism, as is supported by data obtained from RBCs stored in blood bank conditions. A detailed proteomic, lipidomic and immunogenic comparison of microvesicles derived from different sources is essential in the identification of the processes that trigger vesicle generation. The contribution of RBC-derived microvesicles to inflammation, thrombosis and autoimmune reactions emphasizes the need for a better understanding of the mechanisms and consequences of microvesicle generation. Frontiers Media S.A. 2018-06-08 /pmc/articles/PMC6002509/ /pubmed/29937736 http://dx.doi.org/10.3389/fphys.2018.00703 Text en Copyright © 2018 Leal, Adjobo-Hermans and Bosman. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Physiology
Leal, Joames K. F.
Adjobo-Hermans, Merel J. W.
Bosman, Giel J. C. G. M.
Red Blood Cell Homeostasis: Mechanisms and Effects of Microvesicle Generation in Health and Disease
title Red Blood Cell Homeostasis: Mechanisms and Effects of Microvesicle Generation in Health and Disease
title_full Red Blood Cell Homeostasis: Mechanisms and Effects of Microvesicle Generation in Health and Disease
title_fullStr Red Blood Cell Homeostasis: Mechanisms and Effects of Microvesicle Generation in Health and Disease
title_full_unstemmed Red Blood Cell Homeostasis: Mechanisms and Effects of Microvesicle Generation in Health and Disease
title_short Red Blood Cell Homeostasis: Mechanisms and Effects of Microvesicle Generation in Health and Disease
title_sort red blood cell homeostasis: mechanisms and effects of microvesicle generation in health and disease
topic Physiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6002509/
https://www.ncbi.nlm.nih.gov/pubmed/29937736
http://dx.doi.org/10.3389/fphys.2018.00703
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