Quantitative in vivo whole genome motility screen reveals novel therapeutic targets to block cancer metastasis

Metastasis is the most lethal aspect of cancer, yet current therapeutic strategies do not target its key rate-limiting steps. We have previously shown that the entry of cancer cells into the blood stream, or intravasation, is highly dependent upon in vivo cancer cell motility, making it an attractiv...

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Detalles Bibliográficos
Autores principales: Stoletov, Konstantin, Willetts, Lian, Paproski, Robert J., Bond, David J., Raha, Srijan, Jovel, Juan, Adam, Benjamin, Robertson, Amy E., Wong, Francis, Woolner, Emma, Sosnowski, Deborah L., Bismar, Tarek A., Wong, Gane Ka-Shu, Zijlstra, Andries, Lewis, John D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6002534/
https://www.ncbi.nlm.nih.gov/pubmed/29904055
http://dx.doi.org/10.1038/s41467-018-04743-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6002534/
https://www.ncbi.nlm.nih.gov/pubmed/29904055
http://dx.doi.org/10.1038/s41467-018-04743-2

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