Cargando…

Apoptosis in inner ear sensory hair cells

Apoptosis, or controlled cell death, is a normal part of cellular lifespan. Cell death of cochlear hair cells causes deafness; an apoptotic process that is not well understood. Worldwide, 1.3 billion humans suffer some form of hearing loss, while 360 million suffer debilitating hearing loss as a dir...

Descripción completa

Detalles Bibliográficos
Autores principales: Morrill, Seth, He, David Z.Z.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Chinese PLA General Hospital 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6002637/
https://www.ncbi.nlm.nih.gov/pubmed/29937851
http://dx.doi.org/10.1016/j.joto.2017.08.001
_version_ 1783332252527099904
author Morrill, Seth
He, David Z.Z.
author_facet Morrill, Seth
He, David Z.Z.
author_sort Morrill, Seth
collection PubMed
description Apoptosis, or controlled cell death, is a normal part of cellular lifespan. Cell death of cochlear hair cells causes deafness; an apoptotic process that is not well understood. Worldwide, 1.3 billion humans suffer some form of hearing loss, while 360 million suffer debilitating hearing loss as a direct result of the absence of these cochlear hair cells (Worldwide Hearing, 2014). Much is known about apoptosis in other systems and in other cell types thanks to studies done since the mid-20th century. Here we review current literature on apoptosis in general, and causes of deafness and cochlear hair cells loss as a result of apoptosis. The family of B-cell lymphoma (Bcl) proteins are among the most studied and characterized. We will review current literature on the Bcl2 and Bcl6 protein interactions in relation to apoptosis and their possible roles in vulnerability and survival of cochlear hair cells.
format Online
Article
Text
id pubmed-6002637
institution National Center for Biotechnology Information
language English
publishDate 2017
publisher Chinese PLA General Hospital
record_format MEDLINE/PubMed
spelling pubmed-60026372018-06-22 Apoptosis in inner ear sensory hair cells Morrill, Seth He, David Z.Z. J Otol Review Article Apoptosis, or controlled cell death, is a normal part of cellular lifespan. Cell death of cochlear hair cells causes deafness; an apoptotic process that is not well understood. Worldwide, 1.3 billion humans suffer some form of hearing loss, while 360 million suffer debilitating hearing loss as a direct result of the absence of these cochlear hair cells (Worldwide Hearing, 2014). Much is known about apoptosis in other systems and in other cell types thanks to studies done since the mid-20th century. Here we review current literature on apoptosis in general, and causes of deafness and cochlear hair cells loss as a result of apoptosis. The family of B-cell lymphoma (Bcl) proteins are among the most studied and characterized. We will review current literature on the Bcl2 and Bcl6 protein interactions in relation to apoptosis and their possible roles in vulnerability and survival of cochlear hair cells. Chinese PLA General Hospital 2017-12 2017-08-10 /pmc/articles/PMC6002637/ /pubmed/29937851 http://dx.doi.org/10.1016/j.joto.2017.08.001 Text en Copyright © 2017 PLA General Hospital Department of Otolaryngology Head and Neck Surgery. Production and hosting by Elsevier (Singapore) Pte Ltd. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Review Article
Morrill, Seth
He, David Z.Z.
Apoptosis in inner ear sensory hair cells
title Apoptosis in inner ear sensory hair cells
title_full Apoptosis in inner ear sensory hair cells
title_fullStr Apoptosis in inner ear sensory hair cells
title_full_unstemmed Apoptosis in inner ear sensory hair cells
title_short Apoptosis in inner ear sensory hair cells
title_sort apoptosis in inner ear sensory hair cells
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6002637/
https://www.ncbi.nlm.nih.gov/pubmed/29937851
http://dx.doi.org/10.1016/j.joto.2017.08.001
work_keys_str_mv AT morrillseth apoptosisininnerearsensoryhaircells
AT hedavidzz apoptosisininnerearsensoryhaircells