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Apoptosis in inner ear sensory hair cells
Apoptosis, or controlled cell death, is a normal part of cellular lifespan. Cell death of cochlear hair cells causes deafness; an apoptotic process that is not well understood. Worldwide, 1.3 billion humans suffer some form of hearing loss, while 360 million suffer debilitating hearing loss as a dir...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Chinese PLA General Hospital
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6002637/ https://www.ncbi.nlm.nih.gov/pubmed/29937851 http://dx.doi.org/10.1016/j.joto.2017.08.001 |
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author | Morrill, Seth He, David Z.Z. |
author_facet | Morrill, Seth He, David Z.Z. |
author_sort | Morrill, Seth |
collection | PubMed |
description | Apoptosis, or controlled cell death, is a normal part of cellular lifespan. Cell death of cochlear hair cells causes deafness; an apoptotic process that is not well understood. Worldwide, 1.3 billion humans suffer some form of hearing loss, while 360 million suffer debilitating hearing loss as a direct result of the absence of these cochlear hair cells (Worldwide Hearing, 2014). Much is known about apoptosis in other systems and in other cell types thanks to studies done since the mid-20th century. Here we review current literature on apoptosis in general, and causes of deafness and cochlear hair cells loss as a result of apoptosis. The family of B-cell lymphoma (Bcl) proteins are among the most studied and characterized. We will review current literature on the Bcl2 and Bcl6 protein interactions in relation to apoptosis and their possible roles in vulnerability and survival of cochlear hair cells. |
format | Online Article Text |
id | pubmed-6002637 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Chinese PLA General Hospital |
record_format | MEDLINE/PubMed |
spelling | pubmed-60026372018-06-22 Apoptosis in inner ear sensory hair cells Morrill, Seth He, David Z.Z. J Otol Review Article Apoptosis, or controlled cell death, is a normal part of cellular lifespan. Cell death of cochlear hair cells causes deafness; an apoptotic process that is not well understood. Worldwide, 1.3 billion humans suffer some form of hearing loss, while 360 million suffer debilitating hearing loss as a direct result of the absence of these cochlear hair cells (Worldwide Hearing, 2014). Much is known about apoptosis in other systems and in other cell types thanks to studies done since the mid-20th century. Here we review current literature on apoptosis in general, and causes of deafness and cochlear hair cells loss as a result of apoptosis. The family of B-cell lymphoma (Bcl) proteins are among the most studied and characterized. We will review current literature on the Bcl2 and Bcl6 protein interactions in relation to apoptosis and their possible roles in vulnerability and survival of cochlear hair cells. Chinese PLA General Hospital 2017-12 2017-08-10 /pmc/articles/PMC6002637/ /pubmed/29937851 http://dx.doi.org/10.1016/j.joto.2017.08.001 Text en Copyright © 2017 PLA General Hospital Department of Otolaryngology Head and Neck Surgery. Production and hosting by Elsevier (Singapore) Pte Ltd. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Review Article Morrill, Seth He, David Z.Z. Apoptosis in inner ear sensory hair cells |
title | Apoptosis in inner ear sensory hair cells |
title_full | Apoptosis in inner ear sensory hair cells |
title_fullStr | Apoptosis in inner ear sensory hair cells |
title_full_unstemmed | Apoptosis in inner ear sensory hair cells |
title_short | Apoptosis in inner ear sensory hair cells |
title_sort | apoptosis in inner ear sensory hair cells |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6002637/ https://www.ncbi.nlm.nih.gov/pubmed/29937851 http://dx.doi.org/10.1016/j.joto.2017.08.001 |
work_keys_str_mv | AT morrillseth apoptosisininnerearsensoryhaircells AT hedavidzz apoptosisininnerearsensoryhaircells |