Cargando…

Inefficient HIV-1 trans Infection of CD4(+) T Cells by Macrophages from HIV-1 Nonprogressors Is Associated with Altered Membrane Cholesterol and DC-SIGN

Professional antigen-presenting cells (APC; myeloid dendritic cells [DC] and macrophages [MΦ]; B lymphocytes) mediate highly efficient HIV-1 infection of CD4(+) T cells, termed trans infection, that could contribute to HIV-1 pathogenesis. We have previously shown that lower cholesterol content in DC...

Descripción completa

Detalles Bibliográficos
Autores principales:	DeLucia, Diana C., Rinaldo, Charles R., Rappocciolo, Giovanna
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Microbiology 2018
Materias:	Pathogenesis and Immunity
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6002718/ https://www.ncbi.nlm.nih.gov/pubmed/29643243 http://dx.doi.org/10.1128/JVI.00092-18

Ejemplares similares

Control of HIV-1 Pathogenesis in Viremic Nonprogressors Is Independent of Gag-Specific Cytotoxic T Lymphocyte Responses
por: Salgado, Maria, et al.
Publicado: (2018)

Viral and Cellular Factors Leading to the Loss of CD4 Homeostasis in HIV-1 Viremic Nonprogressors
por: Colomer-Lluch, Marta, et al.
Publicado: (2022)

Alterations in Cholesterol Metabolism Restrict HIV-1 Trans Infection in Nonprogressors
por: Rappocciolo, Giovanna, et al.
Publicado: (2014)

HIV-Infected Macrophages Are Infected and Killed by the Interferon-Sensitive Rhabdovirus MG1
por: Sandstrom, Teslin S., et al.
Publicado: (2021)

Characterization of Macrophage-Tropic HIV-1 Infection of Central Nervous System Cells and the Influence of Inflammation
por: Woodburn, Blaide M., et al.
Publicado: (2022)

Role of Escape Mutant-Specific T Cells in Suppression of HIV-1 Replication and Coevolution with HIV-1
por: Zhang, Yu, et al.
Publicado: (2020)

Control of HIV-1 Replication by CD8(+) T Cells Specific for Two Novel Pol Protective Epitopes in HIV-1 Subtype A/E Infection
por: Nguyen, Hung The, et al.
Publicado: (2022)

Expression of HIV-1 Intron-Containing RNA in Microglia Induces Inflammatory Responses
por: Akiyama, Hisashi, et al.
Publicado: (2021)

Immunological Control of HIV-1 Disease Progression by Rare Protective HLA Allele
por: Zhang, Yu, et al.
Publicado: (2022)

A Highly Unusual V1 Region of Env in an Elite Controller of HIV Infection
por: Silver, Zachary A., et al.
Publicado: (2019)

Sequence Evaluation and Comparative Analysis of Novel Assays for Intact Proviral HIV-1 DNA
por: Gaebler, Christian, et al.
Publicado: (2021)

Neutralizing Activity of Broadly Neutralizing Anti-HIV-1 Antibodies against Primary African Isolates
por: Lorenzi, Julio C. C., et al.
Publicado: (2021)

New SHIVs and Improved Design Strategy for Modeling HIV-1 Transmission, Immunopathogenesis, Prevention, and Cure
por: Li, Hui, et al.
Publicado: (2021)

Nonhuman TRIM5 Variants Enhance Recognition of HIV-1-Infected Cells by CD8(+) T Cells
por: Jimenez-Moyano, Esther, et al.
Publicado: (2016)

CD32(+) and PD-1(+) Lymph Node CD4 T Cells Support Persistent HIV-1 Transcription in Treated Aviremic Individuals
por: Noto, Alessandra, et al.
Publicado: (2018)

Effective Suppression of HIV-1 Replication by Cytotoxic T Lymphocytes Specific for Pol Epitopes in Conserved Mosaic Vaccine Immunogens
por: Zou, Chengcheng, et al.
Publicado: (2019)

Altered Immunoglobulin Repertoire and Decreased IgA Somatic Hypermutation in the Gut during Chronic HIV-1 Infection
por: Jones, Sean T., et al.
Publicado: (2022)

HIV-1 Subtype C-Infected Children with Exceptional Neutralization Breadth Exhibit Polyclonal Responses Targeting Known Epitopes
por: Ditse, Zanele, et al.
Publicado: (2018)

Differential Vpu-Mediated CD4 and Tetherin Downregulation Functions among Major HIV-1 Group M Subtypes
por: Umviligihozo, Gisele, et al.
Publicado: (2020)

Limited Evidence for a Relationship between HIV-1 Glycan Shield Features in Early Infection and the Development of Neutralization Breadth
por: Li, Yifan, et al.
Publicado: (2021)

Epitope-dependent effect of long-term cART on maintenance and recovery of HIV-1-specific CD8(+) T cells
por: Kuse, Nozomi, et al.
Publicado: (2023)

New Clues to Understanding HIV Nonprogressors: Low Cholesterol Blocks HIV Trans Infection
por: Prasad, Vinayaka R., et al.
Publicado: (2014)

Structure/Function Studies Involving the V3 Region of the HIV-1 Envelope Delineate Multiple Factors That Affect Neutralization Sensitivity
por: Zolla-Pazner, Susan, et al.
Publicado: (2015)

Deep Gene Sequence Cluster Analyses of Multi-Virus-Infected Mucosal Tissue Reveal Enhanced Transmission of Acute HIV-1
por: Klein, Katja, et al.
Publicado: (2021)

Interleukin-27 Promotes Divergent Effects on HIV-1 Infection in Peripheral Blood Mononuclear Cells through BST-2/Tetherin
por: Temerozo, Jairo R., et al.
Publicado: (2023)

CG Dinucleotide Removal in Bioluminescent and Fluorescent Reporters Improves HIV-1 Replication and Reporter Gene Expression for Dual Imaging in Humanized Mice
por: Roy, Chandra N., et al.
Publicado: (2021)

Impact of Micropolymorphism Outside the Peptide Binding Groove in the Clinically Relevant Allele HLA-C*14 on T Cell Responses in HIV-1 Infection
por: Chikata, Takayuki, et al.
Publicado: (2022)

Evolution of Antibody Responses in HIV-1 CRF01_AE Acute Infection: Founder Envelope V1V2 Impacts the Timing and Magnitude of Autologous Neutralizing Antibodies
por: Kuriakose Gift, Syna, et al.
Publicado: (2023)

Rare Detection of Antiviral Functions of Polyclonal IgA Isolated from Plasma and Breast Milk Compartments in Women Chronically Infected with HIV-1
por: Tay, Matthew Zirui, et al.
Publicado: (2019)

Subtle Longitudinal Alterations in Env Sequence Potentiate Differences in Sensitivity to Broadly Neutralizing Antibodies following Acute HIV-1 Subtype C Infection
por: Mandizvo, Tawanda, et al.
Publicado: (2022)

HIV-1 Nef Induces Hck/Lyn-Dependent Expansion of Myeloid-Derived Suppressor Cells Associated with Elevated Interleukin-17/G-CSF Levels
por: Priceputu, Elena, et al.
Publicado: (2021)

HIV Infection and Persistence in Pulmonary Mucosal Double Negative T Cells In Vivo
por: Meziane, Oussama, et al.
Publicado: (2020)

Structure of an N276-Dependent HIV-1 Neutralizing Antibody Targeting a Rare V5 Glycan Hole Adjacent to the CD4 Binding Site
por: Wibmer, Constantinos Kurt, et al.
Publicado: (2016)

Delayed Expression of PD-1 and TIGIT on HIV-Specific CD8 T Cells in Untreated HLA-B*57:01 Individuals Followed from Early Infection
por: Scharf, Lydia, et al.
Publicado: (2020)

Collaboration of a Detrimental HLA-B*35:01 Allele with HLA-A*24:02 in Coevolution of HIV-1 with T Cells Leading to Poorer Clinical Outcomes
por: Kuse, Nozomi, et al.
Publicado: (2021)

Mechanisms of Abrupt Loss of Virus Control in a Cohort of Previous HIV Controllers
por: Rosás-Umbert, Miriam, et al.
Publicado: (2019)

Impact of HLA Selection Pressure on HIV Fitness at a Population Level in Mexico and Barbados
por: Juarez-Molina, Claudia I., et al.
Publicado: (2014)

HIV Coinfection Provides Insights for the Design of Vaccine Cocktails to Elicit Broadly Neutralizing Antibodies
por: Sheward, Daniel J., et al.
Publicado: (2022)

Effect of Difference in Consensus Sequence between HIV-1 Subtype A/E and Subtype B Viruses on Elicitation of Gag-Specific CD8(+) T Cells and Accumulation of HLA-Associated Escape Mutations
por: Zhang, Yu, et al.
Publicado: (2021)

Axl Deficiency Promotes the Neuroinvasion of Japanese Encephalitis Virus by Enhancing IL-1α Production from Pyroptotic Macrophages
por: Wang, Zhao-Yang, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_ukdsmno9k5jo4pfpm46e64j58k