Evolution-Guided Structural and Functional Analyses of the HERC Family Reveal an Ancient Marine Origin and Determinants of Antiviral Activity

In humans, homologous to the E6-AP carboxyl terminus (HECT) and regulator of chromosome condensation 1 (RCC1)-like domain-containing protein 5 (HERC5) is an interferon-induced protein that inhibits replication of evolutionarily diverse viruses, including human immunodeficiency virus type 1 (HIV-1)....

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Detalles Bibliográficos
Autores principales: Paparisto, Ermela, Woods, Matthew W., Coleman, Macon D., Moghadasi, Seyed A., Kochar, Divjyot S., Tom, Sean K., Kohio, Hinissan P., Gibson, Richard M., Rohringer, Taryn J., Hunt, Nina R., Di Gravio, Eric J., Zhang, Jonathan Y., Tian, Meijuan, Gao, Yong, Arts, Eric J., Barr, Stephen D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2018
Materias:
Virus-Cell Interactions
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6002735/
https://www.ncbi.nlm.nih.gov/pubmed/29669830
http://dx.doi.org/10.1128/JVI.00528-18

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