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Accumulation of Succinate in Cardiac Ischemia Primarily Occurs via Canonical Krebs Cycle Activity

Succinate accumulates during ischemia, and its oxidation at reperfusion drives injury. The mechanism of ischemic succinate accumulation is controversial and is proposed to involve reversal of mitochondrial complex II. Herein, using stable-isotope-resolved metabolomics, we demonstrate that complex II...

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Detalles Bibliográficos
Autores principales:	Zhang, Jimmy, Wang, Yves T., Miller, James H., Day, Mary M., Munger, Joshua C., Brookes, Paul S.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6002783/ https://www.ncbi.nlm.nih.gov/pubmed/29847793 http://dx.doi.org/10.1016/j.celrep.2018.04.104

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