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Atherosclerotic disease is the predominant aetiology of acute coronary syndrome in young adults

OBJECTIVES: Few studies have evaluated young adults in their third and fourth decades with coronary artery disease (CAD). This study evaluated the clinical and angiographic profile of young adults (< 35 years) with CAD. METHODS: A 10-year (2003–2012) retrospective chart reviewwas performed on pat...

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Detalles Bibliográficos
Autores principales: AK, Pillay, DP, Naidoo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Clinics Cardive Publishing 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6002794/
https://www.ncbi.nlm.nih.gov/pubmed/29293260
http://dx.doi.org/10.5830/CVJA-2017-035
Descripción
Sumario:OBJECTIVES: Few studies have evaluated young adults in their third and fourth decades with coronary artery disease (CAD). This study evaluated the clinical and angiographic profile of young adults (< 35 years) with CAD. METHODS: A 10-year (2003–2012) retrospective chart reviewwas performed on patients less than 35 years diagnosed withCAD at Inkosi Albert Luthuli Central Hospital, Durban. RESULTS: Of the 100 patients who met the study criteria, the majority were male (90%), of Indian ethnicity (79%), and presented with acute coronary syndrome (93%). Smoking (82%), dyslipidaemia (79%) and dysglycaemia (75%) were the most prevalent risk factors. Almost half of the subjects (48%) met criteria for the metabolic syndrome. Angiographic findings revealed multi-vessel (42%), single-vessel (36%) and non-occlusive disease (20%); only two subjects had normal epicardial vessels. Disease severity was influenced by dyslipidaemia (p = 0.002) and positive family history (p = 0.002). Non-coronary aetiologies were identified in 19% of subjects. CONCLUSIONS: Atherosclerotic disease associated with risk-factor clustering was highly prevalent in young adults with CAD.