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Crystal structures of binary compounds of meldonium 3-(1,1,1-trimethylhydrazin-1-ium-2-yl)propanoate with sodium bromide and sodium iodide
3-(1,1,1-Trimethylhydrazin-1-ium-2-yl)propanoate (C(6)H(14)N(2)O(2), M, more commonly known under its commercial names Meldonium or Mildronate) co-crystalizes with sodium bromide and sodium iodide forming polymeric hydrates poly[[tetra-μ-aqua-diaquabis[3-(1,1,1-trimethylhydrazin-1-ium-2-yl)p...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
International Union of Crystallography
2018
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6002828/ https://www.ncbi.nlm.nih.gov/pubmed/29951240 http://dx.doi.org/10.1107/S2056989018006977 |
Sumario: | 3-(1,1,1-Trimethylhydrazin-1-ium-2-yl)propanoate (C(6)H(14)N(2)O(2), M, more commonly known under its commercial names Meldonium or Mildronate) co-crystalizes with sodium bromide and sodium iodide forming polymeric hydrates poly[[tetra-μ-aqua-diaquabis[3-(1,1,1-trimethylhydrazin-1-ium-2-yl)propanoate]disodium] dibromide tetrahydrate], [Na(2)(C(6)H(14)N(2)O(2))(2)(H(2)O)(6)]Br(2)·4H(2)O, and poly[[di-μ-aqua-diaqua[μ-3-(1,1,1-trimethylhydrazin-1-ium-2-yl)propanoate]disodium] diiodide], [Na(2)(C(6)H(14)N(2)O(2))(2)(H(2)O)(4)]I(2). The coordination numbers of the sodium ions are 6; the coordination polyhedra can be described as distorted octahedra. Metal ions and M zwitterions are assembled into infinite layers via electrostatic interactions and hydrogen-bonded networks. These layers are connected via electrostatic attraction between halogenide ions and positive trimethylhydrazinium groups into a three-dimensional structure. |
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