Cargando…

Laquinimod protects the optic nerve and retina in an experimental autoimmune encephalomyelitis model

BACKGROUND: The oral immunomodulatory agent laquinimod is currently evaluated for multiple sclerosis (MS) treatment. Phase II and III studies demonstrated a reduction of degenerative processes. In addition to anti-inflammatory effects, laquinimod might have neuroprotective properties, but its impact...

Descripción completa

Detalles Bibliográficos
Autores principales:	Wilmes, Anna T., Reinehr, Sabrina, Kühn, Sandra, Pedreiturria, Xiomara, Petrikowski, Laura, Faissner, Simon, Ayzenberg, Ilya, Stute, Gesa, Gold, Ralf, Dick, H. Burkhard, Kleiter, Ingo, Joachim, Stephanie C.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2018
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6002998/ https://www.ncbi.nlm.nih.gov/pubmed/29903027 http://dx.doi.org/10.1186/s12974-018-1208-3

Ejemplares similares

Progressive Retinal and Optic Nerve Damage in a Mouse Model of Spontaneous Opticospinal Encephalomyelitis
por: Petrikowski, Laura, et al.
Publicado: (2022)

Early remodelling of the extracellular matrix proteins tenascin‐C and phosphacan in retina and optic nerve of an experimental autoimmune glaucoma model
por: Reinehr, Sabrina, et al.
Publicado: (2016)

Analysis of Neurogenesis during Experimental Autoimmune Encephalomyelitis Reveals Pitfalls of Bioluminescence Imaging
por: Ayzenberg, Ilya, et al.
Publicado: (2015)

Fingolimod for Irradiation-Induced Neurodegeneration
por: Metzdorf, Judith, et al.
Publicado: (2019)

S100B immunization triggers NFκB and complement activation in an autoimmune glaucoma model
por: Reinehr, Sabrina, et al.
Publicado: (2018)

Protective effects on the retina after ranibizumab treatment in an ischemia model
por: Joachim, Stephanie C., et al.
Publicado: (2017)

Preserved T-cell response in anti-CD20-treated multiple sclerosis patients following SARS-CoV-2 vaccination
por: Faissner, Simon, et al.
Publicado: (2022)

Ischemic injury leads to extracellular matrix alterations in retina and optic nerve
por: Reinhard, Jacqueline, et al.
Publicado: (2017)

Simultaneous Complement Response via Lectin Pathway in Retina and Optic Nerve in an Experimental Autoimmune Glaucoma Model
por: Reinehr, Sabrina, et al.
Publicado: (2016)

Fingolimod attenuates experimental autoimmune neuritis and contributes to Schwann cell-mediated axonal protection
por: Ambrosius, Björn, et al.
Publicado: (2017)

Clozapine Regulates Microglia and Is Effective in Chronic Experimental Autoimmune Encephalomyelitis
por: Ceylan, Ulaş, et al.
Publicado: (2021)

Intravitreal Therapy Against the Complement Factor C5 Prevents Retinal Degeneration in an Experimental Autoimmune Glaucoma Model
por: Reinehr, Sabrina, et al.
Publicado: (2019)

Capsaicin-enriched diet ameliorates autoimmune neuritis in rats
por: Motte, Jeremias, et al.
Publicado: (2018)

Laquinimod treatment in the R6/2 mouse model
por: Ellrichmann, Gisa, et al.
Publicado: (2017)

Inflammatory demyelination induces glia alterations and ganglion cell loss in the retina of an experimental autoimmune encephalomyelitis model
por: Horstmann, Lioba, et al.
Publicado: (2013)

Fingolimod for multiple sclerosis and emerging indications: appropriate patient selection, safety precautions, and special considerations
por: Ayzenberg, Ilya, et al.
Publicado: (2016)

Synapse and Receptor Alterations in Two Different S100B-Induced Glaucoma-Like Models
por: Benning, Lara, et al.
Publicado: (2020)

Induction of Regulatory Properties in the Intestinal Immune System by Dimethyl Fumarate in Lewis Rat Experimental Autoimmune Neuritis
por: Pitarokoili, Kalliopi, et al.
Publicado: (2019)

Author Correction: Laquinimod treatment in the R6/2 mouse model
por: Ellrichmann, Gisa, et al.
Publicado: (2019)

Aryl Hydrocarbon Receptor Activation in Astrocytes by Laquinimod Ameliorates Autoimmune Inflammation in the CNS
por: Rothhammer, Veit, et al.
Publicado: (2021)

Intrathecal triamcinolone acetonide exerts anti-inflammatory effects on Lewis rat experimental autoimmune neuritis and direct anti-oxidative effects on Schwann cells
por: Pitarokoili, Kalliopi, et al.
Publicado: (2019)

General principles and escalation options of immunotherapy in autoantibody-associated disorders of the CNS
por: Ayzenberg, Ilya, et al.
Publicado: (2019)

Laquinimod in the treatment of multiple sclerosis: a review of the data so far
por: Thöne, Jan, et al.
Publicado: (2016)

Distinctive waves of innate immune response in the retina in experimental autoimmune encephalomyelitis
por: Cruz-Herranz, Andrés, et al.
Publicado: (2021)

Amphiphysin-positive paraneoplastic myelitis and stiff-person syndrome
por: Faissner, Simon, et al.
Publicado: (2016)

Laquinimod Inhibits Inflammation-Induced Angiogenesis in the Cornea
por: Li, Zuohong, et al.
Publicado: (2020)

Laquinimod Supports Remyelination in Non-Supportive Environments
por: Nyamoya, Stella, et al.
Publicado: (2019)

Activation of Apoptosis in a βB1-CTGF Transgenic Mouse Model
por: Weiss, Maximilian, et al.
Publicado: (2021)

Smad7 in T cells drives T helper 1 responses in multiple sclerosis and experimental autoimmune encephalomyelitis
por: Kleiter, Ingo, et al.
Publicado: (2010)

Transfer of the Experimental Autoimmune Glaucoma Model from Rats to Mice—New Options to Study Glaucoma Disease
por: Reinehr, Sabrina, et al.
Publicado: (2019)

Optic Nerve Degeneration after Retinal Ischemia/Reperfusion in a Rodent Model
por: Renner, Marina, et al.
Publicado: (2017)

Microglia Activation in Retinal Ischemia Triggers Cytokine and Toll-Like Receptor Response
por: Wagner, Natalie, et al.
Publicado: (2020)

Prophylactic Glatiramer Acetate Treatment Positively Attenuates Spontaneous Opticospinal Encephalomyelitis
por: Koc, Ümmügülsüm, et al.
Publicado: (2023)

Apoptotic Cell Death in Experimental Autoimmune Encephalomyelitis: Apoptosis of effector cells as a safe mechanism in the termination of an autoimmune inflammatory attack
por: Chan, Andrew, et al.
Publicado: (2005)

Laquinimod Therapy in Multiple Sclerosis: A Comprehensive Review
por: Kolb-Sobieraj, Channa, et al.
Publicado: (2014)

A phase II study of laquinimod in Crohn's disease
por: D'Haens, Geert, et al.
Publicado: (2015)

Dose-dependent immunomodulatory effects of bortezomib in experimental autoimmune neuritis
por: Klimas, Rafael, et al.
Publicado: (2021)

Age-dependent favorable visual recovery despite significant retinal atrophy in pediatric MOGAD: how much retina do you really need to see well?
por: Havla, Joachim, et al.
Publicado: (2021)

Multiple sclerosis is not associated with an increased risk for severe COVID-19: a nationwide retrospective cross-sectional study from Germany
por: Richter, Daniel, et al.
Publicado: (2021)

The impact of the COVID-19 pandemic on hospitalizations and plasmapheresis therapy in multiple sclerosis and neuromyelitis optica spectrum disorder: a nationwide analysis from Germany
por: Richter, Daniel, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_gduut52f9tocphufb9f8p41kjt